Relationship between perioperative anaemia and outcomes in older people with hip fractures: A systematic review and meta-analysis protocol

作     者：Kareeann SF Khow Michelle WK Kee Pazhvoor N Shibu Solomon CY Yu Mellick J Chehade Renuka Visvanathan 

作者机构：Aged and Extended Care Servicesthe Queen Elizabeth HospitalWoodville SouthSA 5011Australia Centre of Research ExcellenceFrailty Trans-disciplinary Research to Achieve Healthy AgeingUniversity of AdelaideAdelaideSA 5005Australia Discipline of Orthopaedics and TraumaFaculty of Medical and Health SciencesUniversity of AdelaideAdelaideSA 5005Australia 

出 版 物：《World Journal of Meta-Analysis》 (世界荟萃分析杂志)

年 卷 期：2019年第7卷第6期

页      面：290-296页

学科分类：10[医学] 

基　　金：National Health and Medical Research Council Postgraduate Scholarship(2017-2018) 

主　　题：Anaemia Haemoglobin Hip fracture Length of stay Mortality Outcomes Perioperative Readmission 

摘      要：BACKGROUND Hip fractures are common with increasing age and is associated with decline in mobility. Both the fracture and the surgery can lead to blood loss, resulting in anaemia. However, it is uncertain at which time point haemoglobin is most strongly associated with different clinical outcomes after hip fracture. Our hypothesis is perioperative anaemia (admission, postoperative and discharge) during hip fracture surgery is associated with poor clinical outcomes. AIM To determine the effects of perioperative anaemia during hip fracture surgery on mortality, functional status and other clinical outcomes. METHODS Electronic databases will be searched to identify studies evaluating perioperative anaemia and outcomes of hip fracture surgery. Reference lists of included studies will also be searched to identify additional published studies. Eligibility criteria are as follows: Population: People who underwent hip fracture surgery;Exposure: Perioperative anaemia;Comparison: No anaemia before or after hip fracture surgery;Outcome: Mortality, hospital length of stay, postoperative complications, hospital readmission, change of discharge destination, quality of life and functional status. Risk of bias assessment will be assessed using the Cochrane Collaboration’s tool for randomized controlled trials and the modified version of the Epidemiological Appraisal Instrument for observational studies. Data will be pooled for meta-analysis if deemed appropriate. CONCLUSION This review seeks to clarify outcomes associated with perioperative anaemia at various time-points around hip fracture surgery. These findings will potentially inform evidence-based clinical practice on interventions in those with anaemia.