Association of image-defined risk factors,tumor resectability,and prognosis in children with localized neuroblastoma
作者机构：Key Laboratory of Pediatric Hematology and OncologyMinistry of HealthDepartment of Pediatric Hematology and OncologyShanghai Children's Medical CenterShanghai Jiaotong University School of Medicine(SJTU-SM)ShanghaiChina
出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)
年 卷 期：2019年第15卷第6期
页 面：572-579页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Image-defined risk factors Localized neuroblastoma Prognosis Surgery
摘 要：Background Although localized neuroblastoma has a good prognosis,some cases have undergone treatment failure or *** from biologic features such as MYCN status,we wondered whether some characteristics of growing tumors are prognostic,such as a well-encapsulated mass without infiltration of vital *** analyzed the diagnostic utility of image-defined risk factors(IDRFs)to predict successful treatment and *** overall goal was to achieve maximum cure rates for patients with localized neuroblastoma through a better understanding of clinical *** We retrospectively reviewed the images of patients with localized neuroblastoma who were enrolled between June 1998 and December 2012 at a single institution in Shanghai,*** categorization regarding IDRFs was available in 67 *** was assessed at diagnosis and after four cycles of neoadjuvant chemotherapy,on *** median follow-up period was 84 months(range: 48-132 months)after *** MRI and CT indicated a total of 177 IDRFs in these 67 *** regression analysis revealed a highly significant negative correlation between the numbers of IDRFs and the possibility of complete removal of *** extension of the tumor,compression of the trachea,and encasement of the main artery in localized neuroblastoma were predictors for incomplete tumor *** to univariate analysis,≥4 IDRFs and intraspinal extension of the tumor were significant indicators of poor *** The number of IDRFs was useful in predicting surgical outcome and event-free *** number of IDRFs should be considered in protocol planning,instead of IDRF presence or absence.
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