Association of image-defined risk factors,tumor resectability,and prognosis in children with localized neuroblastoma
作者机构:Key Laboratory of Pediatric Hematology and OncologyMinistry of HealthDepartment of Pediatric Hematology and OncologyShanghai Children's Medical CenterShanghai Jiaotong University School of Medicine(SJTU-SM)ShanghaiChina
出 版 物:《World Journal of Pediatrics》 (世界儿科杂志(英文版))
年 卷 期:2019年第15卷第6期
页 面:572-579页
核心收录:
学科分类:1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题:Image-defined risk factors Localized neuroblastoma Prognosis Surgery
摘 要:Background Although localized neuroblastoma has a good prognosis,some cases have undergone treatment failure or *** from biologic features such as MYCN status,we wondered whether some characteristics of growing tumors are prognostic,such as a well-encapsulated mass without infiltration of vital *** analyzed the diagnostic utility of image-defined risk factors(IDRFs)to predict successful treatment and *** overall goal was to achieve maximum cure rates for patients with localized neuroblastoma through a better understanding of clinical *** We retrospectively reviewed the images of patients with localized neuroblastoma who were enrolled between June 1998 and December 2012 at a single institution in Shanghai,*** categorization regarding IDRFs was available in 67 *** was assessed at diagnosis and after four cycles of neoadjuvant chemotherapy,on *** median follow-up period was 84 months(range: 48-132 months)after *** MRI and CT indicated a total of 177 IDRFs in these 67 *** regression analysis revealed a highly significant negative correlation between the numbers of IDRFs and the possibility of complete removal of *** extension of the tumor,compression of the trachea,and encasement of the main artery in localized neuroblastoma were predictors for incomplete tumor *** to univariate analysis,≥4 IDRFs and intraspinal extension of the tumor were significant indicators of poor *** The number of IDRFs was useful in predicting surgical outcome and event-free *** number of IDRFs should be considered in protocol planning,instead of IDRF presence or absence.