Distal-less homeobox genes of insects and spiders： genomic organization, function, regulation and evolution

作     者：Bin Chen William H. Piel Antonia Monteiro 

作者机构：Institute of Entomology and Molecular Biology College of Life Sciences Chongqing Normal University Chongqing 401331 P.R. China Yale-NUS College Singapore Department of Biological Sciences National University of Singapore Singapore 

出 版 物：《Insect Science》 (昆虫科学（英文版）)

年 卷 期：2016年第23卷第3期

页      面：335-352页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 07[理学] 09[农学] 0904[农学-植物保护] 090401[农学-植物病理学] 

基　　金：Acknowledgments This work was supported by Par-Eu Scholars Program  and The National Science Foundation (IOB-0516705)  The National Natural Science Foundation of China (31372265)  Coordinated Research Project of the Inter- national Atomic Energy Agency (18268/R0)  National Key Program of Science and Technology Foundation Work of China (2015FY210300)  Singapore Ministry of Education (MOE) AcRF and Yale-NUS College grant numbers IG 14-SI002  IG 15-LR002  R-607-265-052-121  and MOE R-154-000-602-112 and R-154-000-643-112. Wrote the paper: BC  WHP  AM 

主　　题：Distal-less evolution function genomic organization regulation 

摘      要：The Distal-less （DlI） genes are homeodomain transcription factors that are present in most Metazoa and in representatives of all investigated arthropod groups. In Drosophila, the best studied insect, Dll plays an essential role in forming the proximodistal axis of the legs, antennae and analia, and in specifying antennal identity. The initiation of Dll expression in clusters of cells in mid-lateral regions of the Drosophila embryo represents the earliest genetic marker of limbs. Dll genes are involved in the development of the peripheral nervous system and sensitive organs, and they also function as master regulators of black pigmentation in some insect lineages. Here we analyze the complete genomes of six insects, the nematode Caenorhabditis elegans and Homo sapiens, as well as multiple Dll sequences available in databases in order to examine the structure and protein features of these genes. We also review the function, expression, regulation and evolution of arthropod Dll genes with emphasis on insects and spiders.