Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin

作     者：Yiqiong Liu Yunong Sun Xiaoyan Zhao Ji-Young Kim Lu Luo Qian Wang Xiaolu Meng Yonghui Li Nan Sui Zhou-Feng Chen Chuxiong Pan Liang Li Yan Zhang 

作者机构：State Key Laboratory of Membrane Biology College of Life Sciences Peking University Beijing 100871 China Department of Anesthesiology Beijing Tongren Hospital Capital Medical University Beijing 100005 China Department of Anesthesiology Department of Psychiatry Department of Developmental Biology Center for the Study of Itch Washington University School of Medicine Saint Louis MO 63110 USA School of Psychological and Cognitive Sciences Beijing Key Laboratory of Behavior and Mental Health Peking University Beijing 100871 China Beijing Institute for Brain Disorders Beijing 100069 China Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Beijing 100101 China Hendrix College Conway AR 72032 USA PKU-IDG/McGovern Institute for Brain Research Beijing 100871 China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2019年第35卷第5期

页      面：841-852页

核心收录：

学科分类：10[医学] 

基　　金：supported by the National Natural Science Foundation of China (81425009, 31630028, 91632305, 30950030, 31170988, and 81671044) the National Basic Research Development Program (973 Program) of China (2009CB522002) 

主　　题：5-HT Aggression Social isolation Dopamine Lmx1b 

摘      要：Isolation rearing(IR) enhances aggressive behavior, and the central serotonin(5-hydroxytryptamine,5-HT) system has been linked to IR-induced ***, whether the alteration of central serotonin is the cause or consequence of enhanced aggression is still unknown. In the present study, using mice deficient in central serotonin Tph2-/-and Lmx1 b-/-, we examined the association between central serotonin and aggression with or without social isolation. We demonstrated that central serotonergic neurons are critical for the enhanced aggression after IR. 5-HT depletion in wild-type mice increased aggression. On the other hand, application of 5-HT in Lmx1 b-/-mice inhibited the enhancement of aggression under social isolation conditions. Dopamine was downregulated in Lmx1 b-/-mice. Similar to 5-HT, L-DOPA decreased aggression in Lmx1 b-/-mice. Our results linkthe serotoninergic system directly to aggression and this may have clinical implications for aggression-related human conditions.