Crosstalk between gut microbiota and antidiabetic drug action
Crosstalk between gut microbiota and antidiabetic drug action作者机构：Educational and Scientific Centre “Institute of Biology and Medicine” Taras Shevchenko National University of Kyiv Kyiv 01601 Ukraine Endocrinology Department Bogomolets National Medical University Kyiv 01601 Ukraine
出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)
年 卷 期：2019年第10卷第3期
页 面：154-168页
核心收录：
主 题：Type 2 diabetes Gut microbiota Metformin α-glucosidase inhibitors Glucagon-like peptide-1 agonists Peroxisome proliferator-activated receptors γ agonists Dipeptidyl peptidase-4 inhibitors Sodium/glucose cotransporter inhibitors
摘 要：Type 2 diabetes (T2D) is a disorder characterized by chronic inflated blood glucose levels (hyperglycemia), at first due to insulin resistance and unregulated insulin secretion but with tendency towards global spreading. The gut microbiota is recognized to have an influence on T2D, although surveys have not formed a clear overview to date. Because of the interactions between gut microbiota and host homeostasis, intestinal bacteria are believed to play a large role in various diseases, including metabolic syndrome, obesity and associated disease. In this review, we highlight the animal and human studies which have elucidated the roles of metformin,α-glucosidase inhibitors, glucagon-like peptide-1 agonists, peroxisome proliferator-activated receptors γ agonists, inhibitors of dipeptidyl peptidase-4, sodium/glucose cotransporter inhibitors, and other less studied medications on gut microbiota. This review is dedicated to one of the most widespread diseases, T2D, and the currently used antidiabetic drugs and most promising new findings. In general, the gut microbiota has been shown to have an influence on host metabolism, food consumption, satiety, glucose homoeostasis, and weight gain. Altered intestinal microbiota composition has been noticed in cardiovascular diseases, colon cancer, rheumatoid arthritis, T2D, and obesity. Therefore, the main effect of antidiabetic drugs is on the microbiome composition, basically increasing the short-chain fatty acids-producing bacteria, responsible for losing weight and suppressing inflammation.
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