Effect and mechanism of salvianolic acid B on the myocardial ischemiareperfusion injury in rats

作     者：Ling Xue Zhen Wu Xiao-Ping Ji Xia-Qing Gao Yan-Hua Guo 

作者机构：Department of Cardiovascular MedicineQilu HospitalShandong University Department of Cardiovascular MedicineThird Affiliated Hospital of Liaoning Medical College 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2014年第7卷第4期

页      面：280-284页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by Liaoning Provincial Science and Technology Department Project of Liaoning Province(No 2011225015) 

主　　题：Ischemia-reperfusion injury Myocardial infarction Salvianolic acid B Inflammatory response 

摘      要：Objective:To investigate the effect of salvianolic acid B on rats with myocardial ischemiareperfusion ***:SD rats were randomly divided into five groups(n=10 in each group):A sham operation group,B ischemic reperfusion group model group,C low dose salvianolic acid B group,D median dose salvianolic acid B group,E high dose salvianolic acid B *** hour after establishment of the myocardial ischemia-reperfusion model,the concentration and the apoptotic index of the plasma level of myocardial enzymes(CTnⅠ,CKMB),SOD,MDA,NO,ET were,*** tissues were obtained and micro-structural changes were ***:Compared the model group,the plasma CTnⅠ,CK-MB,MDA and ET contents were significantly increased,NO,T-SOD contents were decreased in the treatment group(group C,D,and E)(P0.05);compared with group E,the plasma CTnⅠ,CKMB,MDA and ET levels were increased,the NO,T-SOD levels were decreased in groups C and D(P0.05).Infarct size was significantly reduced,and the myocardial ultrastructural changes were improved significantly in treatment ***:Salvianolic acid B has a significant protective effect on myocardial ischemia-reperfusion *** can alleviate oxidative stress,reduce calcium overload,improve endothelial function and so on.