Kanggan Granule Ameliorates Dexamethasone-Induced Immunosuppression in Mice
Kanggan Granule Ameliorates Dexamethasone-Induced Immunosuppression in Mice作者机构：Department of Pharmacology West China School of Pharmacy Key Laboratory of Drug Targeting and Drug Delivery System Sichuan University Chengdu China Sichuan Engineering Research Center for Medicinal Animals Chengdu China
出 版 物：《Journal of Biosciences and Medicines》 (生物科学与医学（英文）)
年 卷 期：2019年第7卷第3期
页 面：80-91页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Kanggan Granule Immunomodulatory Nonspecific Immunity Humoral Immunity Cellular Immunity
摘 要：Objective: This study was to investigate the effect of the Chinese herbal compound Kanggan granule (KG) on immune function in a mouse model of immunosuppression and its possible mechanism of action. Method: ICR mice were randomly divided into a normal control group (untreated non-immunosuppressed, Control), untreated immunosuppressed group (Model), positive control group (immunosuppressed and treated with 1.6 g/kg astragalus granule [AG]), high-dose KG group (immunosuppressed and treated with 24 g/kg, KG-24), and low-dose KG group (immunosuppressed and treated with 6 g/kg, KG-6). Each group received intragastric administration once daily for 7 days. Immunosuppression was induced by an intraperitoneal injection of dexamethasone (25 mg/kg) once daily beginning on day 1 for 3 days. To illuminate the mechanism of immunomodulatory, we studied the effects of KG on nonspecific immunity, humoral immunity and cellular immunity in mice respectively. Results: KG improved organ weights and improved the phagocytic ability of mononuclear macrophages in immunosuppressed mice (p p 0.05). The proliferation of spleen lymphocytes and number of peripheral blood leukocytes were enhanced after KG treatment in immunosuppressed mice (p +/CD8+ ratio in immunosuppressed mice (p p Conclusions: KG can improve immune function in immunosuppressed mice. Nonspecific immunity, humoral immunity, and cellular immunity were all enhanced.
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