Investigation of hepatoprotective activity of Cyathea gigantea(***.)leaves against paracetamol-induced hepatotoxicity in rats
Investigation of hepatoprotective activity of Cyathea gigantea(***. Hook.) leaves against paracetamol-induced hepatotoxicity in rats作者机构：A.U College of Pharmaceutical SciencesAndhra University
出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)
年 卷 期：2012年第2卷第5期
页 面：352-356页
学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：Supported by University Grants Commission.(No.Fdb/Pharmacy/C6102/2008-2010/5162)
主 题：Hepatoprotective Cyathea gigantea Paracetamol Silymarin Hepatotoxicity
摘 要：Objective:To investigate the hepatoprotective activity of methanolic leaf extract of Cyathea gigantea(***)against paracetamol induced liver damage in ***:The hepatoprotective activity for plant extract was investigated for paracetamol induced hepatoxicity in *** albino rats of either sex were divided into five groups of 6 animals each and are given orally the following treatment for seven *** normal control group was given 1%*** 1mL/kg bw,*** at dose of 1g/kg bw,*** given as toxic dose for inducing ***(50mg/kg.p.o.) was given as reference *** doses of C. gigantea extract i.e.,100 mg/*** 200 mg/kg,*** tested for hepatoprotective activity. The treatment was given for seven days and after 24 h of last treatment blood was collected from retro-orbital plexus and analysed for various serum parameters like serum glutamic-oxaloacetic transaminase(SGOT),serum glutamic pyruvic transaminase(SGPT),alkaline phosphatase(ALP),total bilirubin(TB)and total protein(TP)in different ***:The paracetamol intoxication lead to histological and biochemical *** treatment with methanolic leaf extract of *** reduced the elevated levels of SCOT,SGPT,ALP,TB and also reversed the hepatic damage towards normal which further supports the hepatoprotective activity of leaf extract of ***:The methanolic extract of leaves of *** at doses of 100 mg/kg bw and 200 mg/kg bw have significant effect on liver of paracetamol induced hepatotoxicity model in rats.
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