检索结果-南通市图书馆

Journal of Environmental Sciences 2022年第2期34卷 331-342页

作者： Hussien Ahmed Abbas Rabab Ahmed Nasr Rose-Noelle Vannier Tarek Samir Jamil Inorganic Chemistry Department National Research CentreCairo 12622Egypt Water Pollution Control Department National Research CenterCairo 12622Egypt Univ.Lille CNRSCentrale LilleENSCLUniv.ArtoisUMR 8181Unite de Catalyse et Chimie du Solide(UCCS)Lille 59000France

Nanosized Ba_(1-x)Bi_(x)Fe_(1-x)Cu_(x)O_(3)(12–50 nm)with x values of 0,0.01,0.05,and 0.1 system was prepared using the Pechini method.Structural,morphological,surface and optical characterizations were performed for the prepared samples.Cubic phase was the predominant phase for the undoped BaFeO_(3)and Bi and Cu co-doped BaFeO_(3)samples.Minor phases of monoclinic Ba_(2)Fe_(2)O_(5),orthorhombic BaFe_(2)O_(4)and orthorhombic BaCO_(3)were identified for all the prepared samples.Ba_(0.95)Bi_(0.05)Fe_(0.95)Cu_(0.05)O_(3)sample has the lowest band gap(2.43 e V).98.1%Paracetamol removal was achieved with 0.75 g/L of Ba_(0.95)Bi_(0.05)Fe_(0.95)Cu_(0.05)O_(3)at pH9 after 120 min.The Paracetamol degradation follows the pseudo first-order kinetics.HO·is the main oxidative species responsible for the Paracetamol degradation.Gas chromatography–mass spectrometry(GC–MS)analysis was performed at the end of the photocatalytic degradation experiment under optimum operating condition using Ba_(0.95)Bi_(0.05)Fe_(0.95)Cu_(0.05)O_(3)to explain the reaction mechanism and identify the intermediate by-products which is confirmed by ultraviolet/visible(UV/Vis)spectroscopy study at different reaction times.

关键词： Ba_(1-x)Bi_(x)Fe_(1-x)Cu_(x)O_(3) Photocatalytic degradation Nanomaterials Paracetamol

Nitrogen-doped carbon@TiO_(2) double-shelled hollow spheres as an electrochemical sensor for simultaneous determination of dopamine and Paracetamol in human serum and saliva

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2022年第3期12卷 436-445页

作者： Hui Yang Gongxun Cao Yongjun Huang Ye Lin Fengying Zheng Luxiu Lin Fengjiao Liu Shunxing Li College of Chemistry Chemical Engineering and EnvironmentMinnan Normal UniversityZhangzhouFujian363000China Fujian Provincial Key Laboratory of Pollution Monitoring and Control Minnan Normal UniversityZhangzhouFujian363000China Fujian Key Laboratory of Separation and Analysis Science and Technology ZhangzhouFujian363000China

As the most commonly used antipyretic and analgesic drug,Paracetamol(PA)coexists with neurotransmitter dopamine(DA)in real biological samples.Their simultaneous determination is extremely important for human health,but they also interfere with each other.In order to improve the conductivity,adsorption affinity,sensitivity,and selectivity of TiO_(2)-based electrochemical sensor,N-doped carbon@-TiO_(2) double-shelled hollow sphere(HeC/N@TiO_(2))is designed and synthesized by simple alcoholic and hydrothermal method,using polystyrene sphere(PS)as a template.Meanwhile,TiO_(2) hollow spheres(H eTiO_(2))or N-doped carbon hollow spheres(HeC/N)are also prepared by the same method.HeC/N@TiO_(2) has good conductivity,charge separation,and the highly enhanced and stable current responses for the detection of PA and DA.The detection limit and linear range are 50.0 nmol/L and 0.3-50 mmol/L for PA,40.0 nmol/L and 0.3e50 mmol/L for DA,respectively,which are better than those of carbon-based sensors.Moreover,this electrochemical sensor,with high selectivity,strong anti-interference,high reliability,and long time durability,can be used for the simultaneous detection of PA and DA in human blood serum and saliva.The high electrochemical performance of HeC/N@TiO_(2) is attributed to the multifunctional combination of different layers,because of good conductivity,absorption and electrons transfer ability from in-situ N-doped carbon and electrocatalytic activity from TiO_(2).

关键词： Electrochemical sensor Simultaneous determination Paracetamol Dopamine

Chemically modified carbon-based electrodes for the determination of Paracetamol in drugs and biological samples

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2021年第2期11卷 138-154页

作者： Wafaa Boumya Nawal Taoufik Mounia Achak Noureddine Barka Sultan Moulay Slimane University of Beni Mellal Research Group in Environmental Sciences and Applied Materials(SEMA)FP KhouribgaB.P.14525000KhouribgaMorocco Chouaib Doukkali University Ecole Nationale des Sciences AppliqueesLaboratoire des Sciences de l’Ingenieur pour l’EnergieEl JadidaMorocco Chemical&Biochemical Sciences Green Process EngineeringCBSMohammed VI Polytechnic UniversityBen GuerirMorocco

Paracetamol is a non-steroidal, anti-inflammatory drug widely used in pharmaceutical applications for its sturdy, antipyretic and analgesic action. However, an overdose of Paracetamol can cause fulminant hepatic necrosis and other toxic effects. Thus, the development of advantageous analytical tools to detect and determine Paracetamol is required. Due to simplicity, higher sensitivity and selectivity as well as costefficiency, electrochemical sensors were fully investigated in last decades. This review describes the advancements made in the development of electrochemical sensors for the Paracetamol detection and quantification in pharmaceutical and biological samples. The progress made in electrochemical sensors for the selective detection of Paracetamol in the last 10 years was examined, with a special focus on highly innovative features introduced by nanotechnology. As the literature is rather extensive, we tried to simplify this work by summarizing and grouping electrochemical sensors according to the by which manner their substrates were chemically modified and the analytical performances obtained.

关键词： Paracetamol Electrochemical sensors Modified electrodes Pharmaceutical samples

Development of a microcomposite with single-walled carbon nanotubes and Nd_2O_3 for determination of Paracetamol in pharmaceutical dosage by adsorptive voltammetry

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2019年第1期9卷 62-69页

作者： Verónica Arancibia Johisner Penagos-Llanos Edgar Nagles Olimpo García-Beltrán John J.Hurtado Pontificia Universidad Católica de Chile Facultad de Química Facultad de Ciencias Naturales y Matemáticas Universidad de Ibagué Departamento de Química Universidad de los Andes

This study presents for the first time a new composite of carbon paste(CP), single-walled carbon nanotubes(SWCNTs) and Nd2 O3(NdOX). This versatile composite(NdOX-SWCNT/CPE) was applied to the oxidation of Paracetamol(PCM). The newly formed surface was characterized by scanning electron microscopy(SEM), electrochemical impedance spectroscopy(EIS) and cyclic voltammetry(CV). The results showed greater conductivity and a higher surface area for the composite than those of the carbon paste alone. Moreover, the anodic peak currents for PCM increased from 1.6 to 3.6 m A with CPE and NdOXSWCNT/CPE, indicating an increase of nearly 51.0% for the anodic peak current. On the other hand, the anodic peak potentials shifted from 0.67 to 0.57 V. The detection limits were 0.05 mmol/L with NdOXSWCNT/CPE and 0.50 mmol/L with SWCNT/CPE. The relative standard deviations(RSDs) were 1.5%(n=7). The accuracy and interference of the methods were evaluated with a urine chemistry control spiked with known quantities of PCM, uric acid, dopamine, ascorbic acid, caffeine, acetylsalicylic acid,tartrazine, sunset yellow, allure red, rutin, morin and metal ions. Finally, the novelty and usefulness of the composite were evaluated to quantify PCM in pharmaceutical dosage forms such as tablets, powders and syrups for children.

关键词： Paracetamol Neodymium(Ⅲ) Oxide Single-walled carbon nanotubes Pharmaceutical dosage

Quantification of theophylline or Paracetamol in milk matrices by high-performance liquid chromatography

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2017年第6期7卷 401-405页

作者： Tania A.P.Fernandes Joao P.Aguiara Ana I.Fernandes Joao F.Pinto CiiEM-Centro de Investigacao Interdisciplinar Egas Moniz Instituto Superior de Cinncias da Saude Egas MonizCampus Universitario-Quinta da GranjaMonte de Caparica2829-511 CaparicaPortugal iMed.UL-Dep.Tecnologia Farmaceutica Faeuldade de FarmdciaUniversidade de LisboaAv.Prof.Gama Pinto1649-003 LisboaPortugal

A simple, accurate and sensitive high-performance liquid chromatography （HPLC） method was developed, validated and applied to the determination of either theophylline or Paracetamol in milk-based samples. The method allowed drug quantification in fresh and powdered milk with a relatively short run time of analysis and it was also successfully applied to the quantification of the drugs in solid dosage forms intended for pediatric use. Moreover, the main significant advantages over other published works are the simplicity of the sample preparation, reduced assay time and sample loss. The method meets the International Conference on Harmonization guideline for analytical methods validation regarding specificity, linearity, accuracy, precision, specificity and robustness as required by health authorities and applied by industry while designing and marketing new drug products. The technique encompasses the separation of the analytes with a reverse phase C18 column under isocrafic conditions and UV detection at 272 nm and 243 nm, respectively, for theophylline and paraeetamol. The lower limit of quantification for both drugs was determined as 0.2 μg/mL and the between-batch accuracy was 99.7%. This HPLC method allows quantification of theophylline and Paracetamol in milk matrices and it can be applied in the design, development and production of milk-based pediatric dosage forms.

关键词： Liquid chromatography Fresh milk Powdered milk Paracetamol Theophylline

Hepatotoxicity induced by acute and chronic Paracetamol overdose in children: Where do we stand?

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2017年第1期13卷 76-83页

作者： Hoi Yan Tong Nicolás Medrano Alberto Manuel Borobia JoséAntonio Ruiz Ana María Martínez Julia Martín Manuel Quintana Santos Garcfa Antonio Jos6 Carcas Elena Ramirez Department of Clinical Pharmacology Hospital Universitario La PazIdiPAZSchool of MedicineUniversidad Autónoma de MadridMadridSpain Pediatric Emergency Department Hospital Universitario La PazIdiPAZMadridSpain General Emergency Department Hospital Universitario La PazIdiPAZMadridSpain

Background:There are few data Oll hepatotoxicity induced by acute or chronic Paracetamol poisoning in the pediatric population.Paracetamol poisoning data can reveal the weakn嗍ofParacetamol poisoning management guidelines.Methods:We retrospectively studied the patients of less than 18 years old with measurable Paracetamol levels,who were brought to the emergency department(ED)of La Paz University Hospital,Madrid,Spain,for suspected Paracetamol overdoses between 2005 and 2010.

关键词： acute liver failure hepatotoxicity Paracetamol poisoning

Co3O4/reduced Graphene Oxide Composite as An Enhanced Material for Electrochemical Detection of Paracetamol in Human Serum

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Structural Chemistry 2020年第6期39卷 1035-1043页

作者：陈华林黄启同胡世荣唐淑丽杨浩李占明 College of Chemistry Chemical Engineering and EnvironmentMinnan Normal UniversityZhangzhou 363000China College of Pharmacy Gannati Medical UniversityGanzhou 341000China Department of Food Science China Jiliang UniversityHangzhou 310018China Food Science and Technology Programme Department of ChemistryNational University of SingaporeSingapore 117543Singapore

In this paper,we present a novel,reliable and sensitive electrochemical sensor for the determination of Paracetamol based on hollow carbon Co3O4 nanosheets/reduced graphene oxide composite(Co3O4/r-GO).The Co3O4/r-GO was prepared via a rapid one-step microwave solvothermal process.Some series of techniques that included scanning electron microscopy,X-ray diffraction and Raman were carried out to characterize the morphology and structure of as-prepared materials.Most importantly,the developed electrochemical sensor exhibited a wide linear range of 0.05 to 900.0μM and a low detection limit of 14.0 nM(S/N=3)by using differential pulse voltammetry.Furthermore,the selectivity,repeatability,stability and practical applicability were further studied with satisfactory results.

关键词： Co3O4 nanosheets reduced graphene oxide Paracetamol electrochemical sensor

Analgesic effect of Paracetamol combined with low- dose morphine versus morphine alone on patients with biliary colic： a double blind, randomized controlled trial

在线全文

学校读者我要写书评

暂无评论

World Journal of Emergency Medicine 2016年第1期7卷 25-29页

作者： Mohammad Reza Farnia Rasoul Babaei Farzaneh Shirani Mehdi Momeni Majid Hajimaghsoudi Elnaz Vahidi Morteza Saeedi Emergency Medicine Department Imam Reza Hospital Kermanshah University of Medical Sciences Kermanshah Iran Emergency Medicine Department Shariati Hospital Tehran University of Medical Sciences Tehran Iran Emergency Medicine Research Center Emergency Medicine Department Shariati Hospital Tehran University of Medical Sciences Tehran Iran Emergency Medicine Department Shahid Dr Rahnemoon Hospital Shahid Sadoughi University of Medical Sciences Yazd Iran

BACKGROUND:Numerous drugs have been proposed to alleviate pain in patients with biliary colic,especially opioids,but still there is a tendency to use less narcotics because of their side effects and the unwillingness of some patients.The present study aimed to compare the analgesic effect of Paracetamol combined with low-dose morphine versus morphine alone in patients with biliary colic.METHODS:A randomized double-blind controlled trial was performed in 98 patients with biliary colic,recruited from two emergency departments from August 2012 to August 2013.Eleven patients were excluded and the remaining were randomized into two groups:group A received 0.05mg/kg morphine+1 000 mg Paracetamol in 100 m L normal saline and group B received 0.1 mg/kg morphine+normal saline(100 m L)as placebo.Pain scores were recorded using visual analogue scale(VAS)at baseline and 15 and 30 minutes after drug administration.Adverse effects and the need for rescue medication(0.75 g/kg intravenous fentanyl)were also reported within 60 minutes of drug administration.RESULTS:Before the infusion,the mean±SD VAS scores were 8.73±1.57 in group A and8.53±1.99 in group B.At 15 minutes after drug administration,the mean±SD VAS scores were2.16±1.90 in group A vs.2.51±1.86 in group B;mean difference was–0.35,and 95%CI–1.15 to 0.45(P=0.38).At 30 minutes the mean±SD VAS scores were 1.66±1.59 in group A vs.2.14±1.79 in group B;mean difference was–0.48,and 95%CI–1.20 to 0.24(P=0.19).The mean pain scores in the two groups at 15 and 30 minutes demonstrated no significant difference.CONCLUSION:Paracetamol combined with low-dose morphine may be effective for pain management in patients with biliary colic.

关键词： Biliary colic Morphine Paracetamol Visual analogue scale

Paracetamol Sensitive Cellulose-Based Electrochemical Sensors

在线全文

学校读者我要写书评

暂无评论

Journal of Renewable Materials 2018年第3期6卷 242-250页

作者： Maxime Pontie Serge Foukmeniok Mbokou Jean-Philippe Bouchara Bienvenue Razafimandimby Sylvie Egloff Ornella Dzilingomo Pierre-Yves Pontalier Ignas Kenfack Tonle Host-Pathogen Interaction Study Group(GEIHP EA 3142)UNIV AngersUNIV BrestBretagne Loire UniversityInstitute of Health Biology-IRISCHU4 rue Larrey49933 AngersFrance Electrochemistry and Chemistry of Materials Department of ChemistryUniversity of DschangP.O.Box 67 DschangCameroon Toulouse University INP-ENSIACETLCA(Laboratory of Agro-industrial Chemistry)31030 Toulouse France

Electrochemical determination of Paracetamol(PCT)was successfully performed using carbon paste electrodes(CPEs)modified with treated coffee husks(CHt)or cellulose powder(Ce).Scanning electron microscopy was used to characterize unmodified or modified CPEs prior to their use.The electrochemical oxidation of PCT was investigated using square wave voltammetry(SWV)and cyclic voltammetry(CV).The oxidation current density of PCT was two-fold higher with the CPE-CHt sensor and 30%higher with CPE-Ce in comparison with the unmodified CPE,and this correlated with the higher hydrophilicity of the modified electrodes.Using SWV for the electrochemical analysis of PCT,carbon paste electrode modified with raw coffee husks(CPE-CHr)showed the presence of impurities at+0.27 V/SCE,showing the interest in using pure cellulose for the present analytical application.Furthermore,CPE-Ce presented a higher real area compared to CPE-CHr,which explains the increase in the limit of saturation from 400 mg/L to 950 mg/L.The better saturation limit exhibited by CPE-Ce justifies its choice for electroanalysis of PCT in commercialized tablets.The proposed method was successfully applied in the determination of PCT in commercialized tablets(DolipraneR 500)with a recovery rate close to 100%,and no interference with the excipients contained in the tablets analyzed was observed.This novel sensor opens the way for sustainable development of electroanalytical control of drugs sold individually in developing countries.

关键词： Paracetamol carbon paste electrode coffee husks cellulose fibers square wave voltammetry electroanalysis

A Sensitive Simultaneous Determination of Adrenalin and Paracetamol on a Glassy Carbon Electrode Coated with a Film of Chitosan/Room Temperature Ionic Liquid/Single-Walled Carbon Nanotubes Nanocomposite

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2011年第10期29卷 2157-2164页

作者： Babaei, Ali Babazadeh, Mitra Afrasiabi, Mohammad Department of Chemistry Faculty of Science Arak University Arak 38156-8-8349 Iran Research Center for Nanotechnology University of Arak P.O. Box 38156-879Iran Young Researchers Club Shoushtar Branch Islamic Azad University Shoushtar Iran

The present work demonstrates that simultaneous determination of adrenalin （AD） and Paracetamol （PAR） can be performed on single-walled carbon nanotube/chitosan/ionic liquid modified glassy carbon electrode （SWCNT-CHIT-IL/GCE）. The electro-oxidations of AD and PAR were investigated with cyclic voltammetry （CV）, differential pulse voltammetry （DPV） and also chronoamperometry （CA） methods. DPV experiments showed that the oxidation peak currents of AD and PAR are proportional to the corresponding concentrations over the 1-580 μmol/L and 0.5-400 μmol/L ranges, respectively. The RSD at a concentration level of 15 μmol/L AD and 15 μmol/L PAR were 1.69% and 1.82%, respectively. Finally the modified electrode was used for simultaneous determination of AD and PAR in real samples with satisfactory results.

关键词： modified electrode ionic liquid adrenalin Paracetamol single-wailed carbon nanotubes