Nitrogen-doped carbon@TiO_(2) double-shelled hollow spheres as an electrochemical sensor for simultaneous determination of dopamine and paracetamol in human serum and saliva

作     者：Hui Yang Gongxun Cao Yongjun Huang Ye Lin Fengying Zheng Luxiu Lin Fengjiao Liu Shunxing Li Hui Yang;Gongxun Cao;Yongjun Huang;Ye Lin;Fengying Zheng;Luxiu Lin;Fengjiao Liu;Shunxing Li

作者机构：College of ChemistryChemical Engineering and EnvironmentMinnan Normal UniversityZhangzhouFujian363000China Fujian Provincial Key Laboratory of Pollution Monitoring and ControlMinnan Normal UniversityZhangzhouFujian363000China Fujian Key Laboratory of Separation and Analysis Science and TechnologyZhangzhouFujian363000China 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2022年第12卷第3期

页      面：436-445页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.:22074058 and 21675077) the Project of Industry-University-Research Cooperation of Fujian Province(Grant No.:2019Y4010) the Education-Science Research Project for Young and Middle-aged Teachers of Fujian(Grant No.:JAT200317). 

主　　题：Electrochemical sensor Simultaneous determination Paracetamol Dopamine 

摘      要：As the most commonly used antipyretic and analgesic drug,paracetamol(PA)coexists with neurotransmitter dopamine(DA)in real biological samples.Their simultaneous determination is extremely important for human health,but they also interfere with each other.In order to improve the conductivity,adsorption affinity,sensitivity,and selectivity of TiO_(2)-based electrochemical sensor,N-doped carbon@-TiO_(2) double-shelled hollow sphere(HeC/N@TiO_(2))is designed and synthesized by simple alcoholic and hydrothermal method,using polystyrene sphere(PS)as a template.Meanwhile,TiO_(2) hollow spheres(H eTiO_(2))or N-doped carbon hollow spheres(HeC/N)are also prepared by the same method.HeC/N@TiO_(2) has good conductivity,charge separation,and the highly enhanced and stable current responses for the detection of PA and DA.The detection limit and linear range are 50.0 nmol/L and 0.3-50 mmol/L for PA,40.0 nmol/L and 0.3e50 mmol/L for DA,respectively,which are better than those of carbon-based sensors.Moreover,this electrochemical sensor,with high selectivity,strong anti-interference,high reliability,and long time durability,can be used for the simultaneous detection of PA and DA in human blood serum and saliva.The high electrochemical performance of HeC/N@TiO_(2) is attributed to the multifunctional combination of different layers,because of good conductivity,absorption and electrons transfer ability from in-situ N-doped carbon and electrocatalytic activity from TiO_(2).