Wnt signaling in midbrain dopaminerglc neuron development and regenerative medicine for Parkinson＇s disease

作     者：Ernest Arenas 

作者机构：Laboratory of Molecular Neurobiology Department of Medical Biochemistry and Biophysics Center of Developmental Biology for Regenerative MedicineKarolinska Institute Scheelevag 2 17 117 Stockholm Sweden 

出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)

年 卷 期：2014年第8卷第1期

页      面：42-53页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 0905[农学-畜牧学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090501[农学-动物遗传育种与繁殖] 090102[农学-作物遗传育种] 

基　　金：supported by grants from the Swedish Foundation for Strategic Research (CEDB and SRL Program), Swedish Research Council supported by Karolinska Institutet (SFO Thematic Center in Stem cells and Regenerative Medicine) supported by European Commission (NeuroStemCellRepair and DDPD) 

主　　题：Wntl Wnt5a sFRP stem cells transplantation reprogramming small molecules 

摘      要：Wnts are a highly conserved family of Upid-modified glycoproteins that work as morphogens to activate several signaling pathways, leading to remodeling of the cytoskeleton and the regulation of gene transcription. Wnt signaling regulates multiple cellular functions and cell systems, including the development and maintenance of midbrain dopaminergic （m DA） neurons. These neurons are of consid- erable interest for regenerative medicine because their degeneration results in Parkinson＇s disease （PD）. This review focuses on new advances in understanding key functions of Wnts in mDA neuron development and using novel tools to regulate Wnt signaling in re- generative medicine for PD. Particularly, recent reports indicate that appropriate levels of Wnt signaling are essential to improve the quantity and quality of stem ceil- or reprogrammed ceU-derived mDA neurons to be used in drug discovery and cell replacement therapy for PD.