Azeotropic mixture used for development and validation of Lornoxicam in bulk and its tablet dosage form by spectrophotometric method
Azeotropic mixture used for development and validation of Lornoxicam in bulk and its tablet dosage form by spectrophotometric method作者机构:Department of Pharmaceutical AnalysisInstitute of Research and DevelopmentGujarat Forensic Sciences UniversitySector-18ANr.Police bhavan A.R.College of Pharmacy and G.H.Patel Institute of Pharmacy
出 版 物:《Journal of Pharmaceutical Analysis》 (药物分析学报(英文版))
年 卷 期:2012年第2卷第4期
页 面:306-309页
学科分类:1007[医学-药学(可授医学、理学学位)] 10[医学]
主 题:Analgesic Chlortenoxicam Lornoxicam Oxicam Spectrophotometric Azeotropic mixture
摘 要:A novel,safe,economic and sensitive method of spectrophotometric estimation has been developed using Azeoptropic mixture (water∶methanol:60∶40,v/v) for the quantitative determination of Lornoxicam,a practically water-insoluble ***,Lornoxicam stock solution was prepared in Azeoptropic *** showed maximum absorbance at 383 *** s law was obeyed in the concentration range 4-24 μg/mL with regression coefficient of *** method was validated in terms of linearity (R2=0.999),precision (CV for intra-day and inter-day was 0.28 0.68 and 0.12-0.92,respectively),accuracy (98.03-100.59% w/w) and *** method is simple,precise,accurate,sensitive and reproducible and can be used for the routine quality control testing of the marketed formulations.