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Azeotropic mixture used for development and validation of lornoxicam in bulk and its tablet dosage form by spectrophotometric method

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Journal of Pharmaceutical Analysis 2012年第4期2卷 306-309页

作者： Prajesh Prajapati Vipul Vaghela Deepak Rawtani Harshad Patel Jasmin Kubavat Dharmendra Baraiya Department of Pharmaceutical Analysis Institute of Research and DevelopmentGujarat Forensic Sciences UniversitySector-18ANr.Police bhavan A.R.College of Pharmacy and G.H.Patel Institute of Pharmacy

A novel,safe,economic and sensitive method of spectrophotometric estimation has been developed using Azeoptropic mixture (water∶methanol:60∶40,v/v) for the quantitative determination of lornoxicam,a practically water-insoluble ***,lornoxicam stock solution was prepared in Azeoptropic *** showed maximum absorbance at 383 ***'s law was obeyed in the concentration range 4-24 μg/mL with regression coefficient of *** method was validated in terms of linearity (R2=0.999),precision (CV for intra-day and inter-day was 0.28 0.68 and 0.12-0.92,respectively),accuracy (98.03-100.59％ w/w) and *** method is simple,precise,accurate,sensitive and reproducible and can be used for the routine quality control testing of the marketed formulations.

关键词： Analgesic Chlortenoxicam lornoxicam Oxicam Spectrophotometric Azeotropic mixture

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Effect of Ultrasound-Guided Transversus Abdominis Plane Block Combined with lornoxicam on Pain and Recovery Quality After Abdominal Surgery in Patients with Drug Addiction

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Journal of Clinical and Nursing Research 2023年第5期7卷 89-96页

作者： Ling Luo Zhouxu Yang Hongtao Yang The First People's Hospital of Liangshan Yi Autonomous Prefecture Liangshan 615000Sichuan ProvinceChina People's Hospital of Butuo County Liangshan Yi Autonomous PrefectureLiangshan 615000Sichuan ProvinceChina

Objective:This paper aims to analyze the analgesic effect of ultrasound-guided transversus abdominis plane block(TAPB)combined with non-steroidal anti-inflammatory analgesic drug lornoxicam on abdominal surgery in patients with a history of drug ***:32 patients aged 18-60 who underwent lower abdominal surgery in the First People's Hospital of Liangshan Yi Autonomous Prefecture and Butuo County People's Hospital of Liangshan Yi Autonomous Prefecture from January 2022 to March 2023 were selected,the patients must have drug abuse history for more than 1 year,with a history of drug withdrawal and *** patients were divided into observation group and control group by the envelope method,with 16 cases in the observation group and 16 cases in the control *** groups of patients underwent ultrasound-guided bilateral transversus abdominis plane block after the *** observation group was treated with dexmedetomidine hydrochloride 1μg/kg+0.25%ropivacaine hydrochloride 40ml,and the control group was treated with 40ml 0.9%sodium chloride injection,the two groups of patients returned to the ward after operation and given intravenous infusion of lornoxicam for relieving the *** visual analogue scale(VAS)score of postoperative pain,the times of rescue analgesia,the time of postoperative anal exhaust,the time of ambulation,nausea and vomiting,withdrawal symptoms,related adverse reactions,and hospitalization days were compared between the two ***:The VAS score of postoperative pain in the observation group was significantly lower than that in the control group,P*** time to get out of bed and the length of hospital stay were not significantly different be

关键词： Ultrasound-guided transversus abdominis plane block lornoxicam Patients with drug addiction Nursing effect

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