Relevance of placental type I interferon beta regulation for pregnancy success

作     者：Ja-Young Kwon Paulomi Aldo Yuan You Jiahui Ding Karen Racicot Xiaoyan Dong John Murphy Guy Glukshtad Michelle Silasi Jian Peng Li Wen Vikki MAbrahams Roberto Romero Gil Mor 

作者机构：Division of Reproductive SciencesDepartment of ObstetricsGynecology and Reproductive SciencesYale School of MedicineNew HavenCTUSA Department of Obstetrics and GynecologyInstitute of Women’s Life Medical ScienceYonsei University College of MedicineSeoulKorea Department of ObstetricsGynecology&Reproductive BiologyCollege of Human MedicineMichigan State University400 Monroe Avenue NEGrand RapidsMI 49503USA Department of PulmonaryShanghai Children’s HospitalShanghai Jiaotong University School of MedicineShanghaiChina Division of EndocrinologyDepartment of Internal MedicineYale School of MedicineNew HavenCTUSA Perinatal Research BranchNICHD/NIHDetroitMIUSA 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2018年第15卷第12期

页      面：1010-1026页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This study is in part funded by grants P01HD054713 R56AI124356 and 3N01 HD23342 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Department of Health and Human Services 

主　　题：trophoblast immune regulation cytokine TAM receptors type I interferon Interferon beta ISGs 

摘      要：Pregnancy is a unique immunologic and microbial condition that requires an adequate level of awareness to provide a fast and protective response against pathogens as well as to maintain a state of tolerance to paternal *** of inflammatory pathways in the placenta triggered by pathogens is one of the main factors responsible for pregnancy *** I IFNs are key molecules modulating immune responses at the level of the placenta and are crucial for protection of the pregnancy via their antiviral and immune modulatory *** this study,we elucidate the mechanisms controlling the basal expression of IFNβand its negative *** in vitro and in vivo animal models,we found that TLR signaling maintains basal IFNβlevels through the TLR4-MyD88-independent TBK/IRF3 signaling *** describe the role of the TAM receptor Axl in the regulation of IFNβfunction in human and mouse trophoblast *** absence of TAM receptors in vivo is associated with fetal demise due to dysregulation of IFNβexpression and its pro-apoptotic downstream ***,our data describe a feedback signaling pathway controlling the expression and function of IFNβin the trophoblast that is essential for an effective response during viral and microbial infections.