Genetics of coronary heart disease with reference to ApoAICⅡI-AIV gene region

作     者：Suraksha Agrawal Sarabjit Mastana 

作者机构：Department of Medical GeneticsSanjay Gandhi Post Graduate Institute of Medical SciencesLucknow UP 226014India Human Genomics LabSchool of SportExercise and Health SciencesLoughborough UniversityLoughborough LE11 3TUUnited Kingdom 

出 版 物：《World Journal of Cardiology》 (世界心脏病学杂志（英文版）（电子版）)

年 卷 期：2014年第6卷第8期

页      面：755-763页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：ApoAI-CⅡI-AIV gene cluster Haplotype analysis Single nucleotide polymorphism Candidate gene study Genome wide association studies 

摘      要：Cardiovascular diseases are affected by multiple factors like genetic as well as environmental hence they reveal factorial nature. The evidences that genetic factors are susceptible for developing cardiovascular diseases come from twin studies and familial aggregation. Different ethnic populations reveal differences in the prevalence coronary artery disease(CAD) pointing towards the genetic susceptibility. With progression in molecular techniques different developments have been made to comprehend the disease physiology. Molecular markers have also assisted to recognize genes that may provide evidences to evaluate the role of genetic factors in causation of susceptibility towards CAD. Numerous studies suggest the contribution of specific candidate genes, which correlate with various roles/pathways that are involved in the coronary heart disease. Different studies have revealed that there are large numbers of genes which are involved towards the predisposition of CAD. However, these reports are not consistent. One of the reasons could be weak contribution of genetic susceptibility of these genes. Genome wide associations show different chromosomal locations which dock, earlier unknown, genes which may attribute to CAD. In the present review different ApoAI-CⅡI-AIV gene clusters have been discussed.