Prognostic Significance of Hematologic Markers in Patients with Head and Neck Squamous Cell Carcinomas

作     者：Ryohei Oya Yukinori Takenaka Kengo Aoki Hiroko Hamaguchi Kazuya Takemura Masayuki Nozawa Takahiro Kitamura Yoshifumi Yamamoto Atsuhiko Uno 

作者机构：Department of Otorhinolaryngology-Head and Neck Surgery Osaka General Medical Center Osaka Japan Department of Otorhinolaryngology-Head and Neck Surgery Osaka University Graduate School of Medicine Osaka Japan Department of Otorhinolaryngology-Head and Neck Surgery Kansai Medical Hospital Osaka Japan 

出 版 物：《International Journal of Otolaryngology and Head & Neck Surgery》 (耳鼻喉（英文）)

年 卷 期：2018年第7卷第2期

页      面：55-65页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Biomarkers Head and Neck Cancer Hematologic Marker 

摘      要：Aim: To assess the prognostic value of hematologic markers for cancers of the head and neck region, according to tumor site. Methods: We reviewed the data of 441 patients diagnosed with head and neck squamous cell carcinomas (HNSCC) between 2006 and 2014. Overall survival rates were estimated using the Kaplan-Meier method and Cox proportional hazards models were used to assess the hazard ratio (HR) for death, according to hematologic markers. Results: In the univariate analyses, hemoglobin concentration;leukocyte, neutrophil, monocyte, and platelet counts;and the platelet-lymphocyte ratio were associated with overall survival. In the multivariate analyses, hemoglobin concentration (HR 0.55, 95% confidence interval [CI] 0.38 - 0.78, p Conclusions: Several hematologic markers have prognostic significance for patients with HNSCC, however, the magnitude of the effect depends on the tumor site.