<i>Datura metel</i>Administration Distorts Medial Prefrontal Cortex Histology of Wistar Rats

作     者：Temitope Akhigbe Etibor Musa Iyiola Ajibola Mohammad Olanrewaju Buhari Abass Alao Safiriyu Oluwole Busayo Akinola Ezekiel A. Caxton-Martins 

作者机构：Department of Human Anatomy Kampala International University Western Campus Ishaka Bushenyi Uganda Department of Physiology Kampala International University Western Campus Ishaka Bushenyi Uganda Department of Anatomy University of Ilorin Ilorin Nigeria 

出 版 物：《World Journal of Neuroscience》 (神经科学国际期刊（英文）)

年 卷 期：2015年第5卷第4期

页      面：282-291页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：D. metel Nissl Substance Prefrontal Cortex Chromatolysis 

摘      要：Datura metel is one of psychoactive substances of great ethno-pharmacological significance often abused because of its unrestricted availability, yet, little is known about its mechanisms of action. This work was therefore aimed at assessing the activity of ethanolic seed extract of D. metel on Nissl substances, astrocytes, axonal and neuronal integrity of the medial prefrontal cortex (mPFC) of Wistar rats. Eighteen Wistar rats averaging 175 g were used and randomly assigned to three groups: group A rats (n = 6) were administered extract of 100 mg/kg bw, group B rats (n = 6) received extract of 200 mg/kg bw, and group C-control (n = 6) took distilled water only for 14 days. The results revealed that D. metel is deleterious to the health of Wistar rats at a dose-dependent rate as observed in its actions on the medial prefrontal cortex at 100 mg/kg bw and 200 mg/kg bw. The histological study of the treated Wistar rats exhibited features of disoriented neuronal integrity such as, chromatolysis, reduced protein synthesis due to loss of Nissl substances and nuclei, neuronal loss as well as axonal injuries.