Autologous Peripheral Blood Stem Cells and <i>γ</i>/<i>δ</i>T Cells May Improve Immunity in Treating Secondary Bacteremic Infection in HIV Infected Patient
Autologous Peripheral Blood Stem Cells and <i>γ</i>/<i>δ</i>T Cells May Improve Immunity in Treating Secondary Bacteremic Infection in HIV Infected Patient作者机构：Division of Internal Medicine The Human Medicine International Clinic Ho Chi Minh City Vietnam Molecular Diagnostics Department Nam Khoa-Biotek Laboratory Ho Chi Minh City Vietnam Division of Pathology The Human Medicine International Clinic Ho Chi Minh City Vietnam Department of Pathology National Institute of Infectious Diseases Tokyo Japa Sol Price School of Public Policy University of Southern California Los Angeles CA USA Section of Surgery Newport Specialty Hospital Tustin CA USA
出 版 物：《Stem Cell Discovery》 (干细胞探索（英文）)
年 卷 期：2015年第5卷第4期
页 面：48-61页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Human Peripheral Blood Stem Cells γ/δ T Cells NK Cells Hematopoietic Stem Cells CD4 CD8 HIV
摘 要：Opportunistic bacteremia in adult HIV-infected patients is a normal co-infectious condition caused by Gram-negative bacilli. Respiratory infections, including cough, shortness of breath, and chest pain and skin infection with eruptions, pustules and itchiness, are common complaints in the setting of late HIV infection. The variety of infections ranges from mild, self-limited viral, bacteremia and fungal infections to severe, life-threatening demanding urgent care and hospitalization. Varicella pneumonia, for instance, is the most severe complication of chickenpox in HIV infected adults, potentially refractory, fulminant respiratory failure can ensue. Patients with impaired immune status and chronic lung disease are at an increased risk. In the United States as well as in Vietnam, bacterial/viral pneumonia and skin infection are the two most common HIV-associated conditions. While globally the incidence of opportunistic infection has decreased since the introduction of highly active antiretroviral therapy during the last 3 decades, HIV-associated diseases remain a significant source of mortality, thus any manifestation must be taken seriously. This study will present the most common HIV-related pulmonary and skin infections and provide an overview of the epidemiology, characteristic clinical and chest radiograph findings, diagnosis, treatment, and prevention globally as well in Vietnam. Though the extensive efforts of the Vietnamese Government during last decade contributed to a valuable decrease, yet epidemic in Vietnam still remains high, ranking Vietnam 5th in the South-East region. The second part of the study focuses on a unique and severe HIV case report of a 35-year-old man, with a rare form of pneumonia caused by Acitenobacter spp. concomitant with a prolonged and disseminating skin infection. The case has been treated with a combination of conventional anti-retroviral medication and autologous peripheral blood stem cells, the results showed that within 5 mon
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