Synthesis of （-）-Harzialactone A from a Readily Accessible Epoxy Chiral Building Block

作     者：何蕾 张少敏 伍贻康 李焰 

作者机构：Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules and School of Chemistry and Chemical Engineering Hubei University Wuhan Hubei 430062 China State Key Laboratory of Bioorganic and Natural Products Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2011年第29卷第12期

页      面：2664-2668页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 081304[工学-建筑技术科学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 0813[工学-建筑学] 

基　　金：Project supported by the National Basic Research Program of China (973 Program) (No. 2010CB833200)  the National Natural Science Foundation of China (Nos. 21172247  21032002  20921091  20672129  20621062  2(1772143) and the Chinese Academy of Sciences ("Knowledge Innovation"  No. KJCX2.YW.H08) 

主　　题：natural products chiral building blocks epoxides lactones condensation 

摘      要：The antipode of （＋）-harzialactone A, an antitumor marine metabolite, was synthesized with the two stereogenic centers in the target structure taken from an optically active epoxy cbiral building block.