Antitumor and Antifungal Activities of Organic Extracts of Seacucumber Holothuria atra from the Southeast Coast of India

作     者：Devaraj Isaac DHINAKARAN Aaron Premnath LIPTON 

作者机构：Center for Marine Science and Technology Manonmaniam Sundaranar University Marine Biotechnology Laboratory Central Marine Fisheries Research Institute 

出 版 物：《Journal of Ocean University of China》 (中国海洋大学学报（英文版）)

年 卷 期：2015年第14卷第1期

页      面：185-189页

核心收录：

学科分类：0710[理学-生物学] 1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 0908[农学-水产] 0707[理学-海洋科学] 0815[工学-水利工程] 0824[工学-船舶与海洋工程] 100602[医学-中西医结合临床] 10[医学] 

主　　题：有机提取物 抗肿瘤活性 抑菌活性 海参 东南沿海 生物活性化合物 白色念珠菌 抗真菌活性 

摘      要：In phylum Echinodermata, the family Holothuridae is distinguished by its capacity of bioactive compounds. Sea cucumber Holothuria atra is commonly known as the lollyfish. The antifungal activity was detected using agar well diffusion method against the various fungal strains such as Trichoderma viride, Aspergillus niger, Aspergillus flavis, Candida albicans and Penicillium chrysogenum. Relatively high antifungal activity was seen against Candida albicans at 100 μL-1 concentration of extracts. Zone of inhibition was measured at 18 mm of diameter. The anti-tumor activities were detected against the Vero and Hep2 cell lines using MTT assay. The cells were treated with H. atra extract at concentrations 0.078-10 mg m L-1. The extract showed high proliferative activity against the Hep2 cells. The body wall extracts of sea cucumber(H. atra) showed effective antifungal and antitumor activities. All these findings suggest that the extracts could be used for the development of drugs.