Bistachybotrysins D and E,one stereoisomeric pair of cytotoxic phenylspirodrimane dimers from Stachybotrys chartarum

作     者：Min Zhang Jiamin Feng Xiaona Jia Jinlian Zhao Jimei Liu Ridao Chen Kebo Xie Dawei Chen Yan Li Dan Zhang Jungui Dai 

作者机构：State Key Laboratory of Bioactive Substance and Function of Natural MedicinesInstitute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Key Laboratory of Biosynthesis of Natural Products of National Health and Family Planning Commission Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2019年第30卷第2期

页      面：435-438页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：financially supported by CAMS Innovation Fund for Medical Sciences (Nos. CIFMS-2016-I2M-3-012 and CAMS-I2M2-002) 

主　　题：Bistachybotrysin Stereoisomeric pair Phenylspirodrimane dimer Cytotoxic activity Stachybotrys chartarum 

摘      要：Bistachybotrysins D and E (1 and 2), one stereoisomeric pair of phenylspirodrimane dimers, were isolated from Stachybotrys chartarum CGMCC 3.5365. They represent novel phenylspirodrimane dimers with a central [6,5,6]-tricyclic carbon scaffold containing a cyclopentanone core. The structures of 1 and 2 were elucidated through extensive spectroscopic data analysis, and their absolute configurations were characterized by calculated electronic circular dichroism (ECD). Compounds 1 and 2 displayed potent cytotoxic activity against the four human tumor cell lines HCT116, BGC823, Daoy and HepG2 with IC_ (50)values ranging from 6.7 μmol/L to 11.6 μmol/L. Furthermore, a plausible biogenetic pathway for 1 and 2 is proposed.