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Potential role of the gut microbiota in synthetic torpor and therapeutic hypothermia

Potential role of the gut microbiota in synthetic torpor and therapeutic hypothermia

作     者:Claudia Sisa Silvia Turroni Roberto Amici Patrizia Brigidi Marco Candela Matteo Cerri 

作者机构:Department of Biomedical and Neuromotor SciencesUniversity of Bologna40126 BolognaItaly Unit of Microbial Ecology of HealthDepartment of Pharmacy and BiotechnologyUniversity of Bologna40126 BolognaItaly 

出 版 物:《World Journal of Gastroenterology》 (世界胃肠病学杂志(英文版))

年 卷 期:2017年第23卷第3期

页      面:406-413页

核心收录:

学科分类:1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

主  题:Therapeutic hypothermia Gut microbiota Hibernation Dysbiosis Synthetictorpor 

摘      要:Therapeutic hypothermia is today used in several clinical settings, among them the gut related diseases that are influenced by ischemia/reperfusion injury. This perspective paved the way to the study of hibernation physiology, in natural hibernators, highlighting an unexpected importance of the gut microbial ecosystem in hibernation and torpor. In natural hibernators, intestinal microbes adaptively reorganize their structural configuration during torpor, and maintain a mutualistic configuration regardless of long periods of fasting and cold temperatures. This allows the gut microbiome to provide the host with metabolites, which are essential to keep the host immunological and metabolic homeostasis during hibernation. The emerging role of the gut microbiota in the hibernation process suggests the importance of maintaining a mutualistic gut microbiota configuration in the application of therapeutic hypothermia as well as in the development of new strategy such as the use of synthetic torpor in humans. The possible utilization of tailored probiotics to mold the gut ecosystem during therapeutic hypothermia can also be taken into consideration as new therapeutic strategy.

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