A New Perspective for Chinese Medicine Intervention for Coronary Artery Disease: Targeting Inflammation

作     者：LI Si-ming LI Jin-gen XU Hao 

作者机构：Cardiovascular Diseases Center Xiyuan Hospital China Academy of Chinese Medical Sciences Graduate School Beijing University of Chinese Medicine 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2019年第25卷第1期

页      面：3-8页

核心收录：

学科分类：10[医学] 

基　　金：Supported by the Beijing Municipal Science and Technology Commission(No.Z151100004015090) 

主　　题：coronary artery disease inflammation Chinese medicine 

摘      要：Inflammation, which plays a critical role in atherosclerosis and the occurrence of acute cardiovascular events, may be a new target for treatment of coronary artery disease(CAD) to reduce residual cardiovascular risk. Recently, Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease(CANTOS), the largest scale clinical trial that targeted inflammation but not lipids, has affirmed for the first time the inflammatory hypothesis of artherosclerosis and marked the advent of an exciting era of targeting inflammation for the prevention and treatment of cardiovascular diseases. Chinese medicine(CM) is a promising adjuvant therapy for CAD in light of its safety and pleiotropic effect of anti-inflammation, anti-platelet, lipid-regulating, endothelium-protection, microcirculation-improving, etc. In recent years, exploration of anti-inflammatory treatment of CAD with CM has been going on from theory to practice. Taking CANTOS as an example, the design strategy to combine CM and Western medicine to inhibit inflammation were discussed in this paper, which might provide a new perspective for CM intervention on CAD.