White matter alterations in anorexia nervosa: A systematic review of diffusion tensor imaging studies

作     者：Beatriz Martin Monzon Phillipa Hay Nasim Foroughi Stephen Touyz 

作者机构：Centre for Health ResearchSchool of MedicineWestern Sydney University School of PsychologyFaculty of ScienceUniversity of Sydney 

出 版 物：《World Journal of Psychiatry》 (世界精神病学杂志)

年 卷 期：2016年第6卷第1期

页      面：177-186页

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：Shire Pharmaceuticals Jansen-Cilag Western Sydney University 

主　　题：Eating disorder Diffusion tensor imaging Weight/shape overvaluation Food anxiety 

摘      要：AIM: To identify findings concerning white matter(WM) fibre microstructural alterations in anorexia nervosa(AN).METHODS: A systematic electronic search was undertaken in several databases up to April 2015. The search strategy aimed to locate all studies published in English or Spanish that included participants with AN and which investigated WM using diffusion tensor imaging(DTI). Trials were assessed for quality assessment according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses checklist and a published quality index guideline. RESULTS: A total of 6 studies met the inclusion criteria, four of people in the acute state of the illness, one included both recovered and unwell participants, and one included people who had recovered. Participants were female with ages ranging from 14 to 29 years. All studies but one measured a range of psychopathological features. Fractional anisotropy and mean diffusivity were the main DTI correlates reported. Alterations were reported in a range of WM structures of the limbicsystem, most often of the fornix and cingulum as well as the fronto-occipital fibre tracts, i.e., regions associated with anxiety, body image and cognitive function. Subtle abnormalities also appeared to persist after ***: This diversity likely reflects the symptom complexity of AN. However, there were few studies, they applied different methodologies, and all were cross-sectional.