Mast cell stabilizing and antiallergic activity of Abrus precatorius in the management of asthma

作     者：DJ Taur RY Patil 

作者机构：Department of PharmacognosyS.V.P.M's College of PharmacyMalegaon(bk)Baramati-413115MaharashtraIndia Department of PharmacognosyPDEA's S.U.College of Pharmaceutical Sciences and Research CenterKharadiPune-411014MaharashtraIndia 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2011年第4卷第1期

页      面：46-49页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Abrus precatorius Asthma Mast cell Allergy 

摘      要：Objective:To investigate effects of ethanol extract of Abrus precatorius leaves（EAPL） on egg albumin induced mast cell degranulation in mice and passive cutaneous anaphylaxis in rats. Methods:In present study ethanol extract of Abrus precatorius leaves（EAPL） at doses of 100,125, 150 mg/kg i.p were evaluated for preliminary phytochemical screening,acute toxicity studies and egg albumin induced mast cell degranulation in mice and passive cutaneous anaphylaxis in rats. Results:The results of present investigation showed that the LD50 of EAPL is more than 1300 mg/ ***（100-150 mg/kg,i.p.） significantly protect egg albumin induced degranulation of mast cell and inhibit area of leakage of dye in passive cutaneous *** studies observed presence of saponin,alkaloids,flavonoids,and ***:In conclusion EAPL possesses anti asthmatic potential.