检索结果-南通市图书馆

Asian Pacific Journal of Tropical Biomedicine 2019年第6期9卷 249-256页

作者： Wan Suriyani Wan-Ibrahim Norzila Ismail Siti Farhanah Mohd-Salleh Aidy Irman Yajid Michael Pak-KaiWong Mohd Nizam Md Hashim Department of Pharmacology School of Medical SciencesUniversiti Sains Malaysia16150Kubang KerianKelantanMalaysia Department of Pathology School of Medical SciencesUniversiti Sains Malaysia16150Kubang KerianKelantanMalaysia Department of Surgery School of Medical SciencesUniversiti Sains Malaysia16150Kubang KerianKelantanMalaysia

Objective:To determine the anti-proliferative activity of Abrus precatorius(***)leaf extracts and their effect on cell ***:*** leaves were extracted successively with hexane,ethyl acetate and methanol by Soxhlet *** extract was prepared by decoction at 50 ℃.Extracts of *** leaves were used to treat selected cancer and normal cell lines for72 ***,3-(4,5-dimethyl thiazol-2-yl)2,5-diphenyl tetrazolium bromide assay was performed to determine cell *** of cell cycle arrest,apoptosis assay and apoptosis protein expressions were determined by flow ***:Methanolic extract of *** leaves showed the lowest IC50 on MDA-MB-231 cells at(26.40±5.40)μg/*** cytometry analysis revealed that cell arrest occurred at G0/G1 phase and the apoptosis assay showed the occurrence of early apoptosis at 48 h in MDAMB-231 cells treated with methanolic extract of *** *** extract of *** leaves induced apoptosis by upregulation of Bax,p53 and caspase-3 and downregulation of ***:Methanolic extract of A precatorius leaves promotes MDA-MB-231 cell death by inducing cell cycle arrest and apoptosis possibly via the mitochondrial-related pathway.

关键词： Abrus precatorius MDA-MB-231 Apoptosis Cell cycle Breast cancer

Antitrypanosomal potentials of the extract and fractions of Abrus precatorius seeds

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2012年第11期5卷 857-861页

作者： Nwodo NJ Nwodo OFC Department of Pharmaceutical Chemistry University of NigeriaNsukka Nigeria Department of Biochemistry University of NigeriaNsukka Nigeria

Objective:To evaluate the in vivo trypanocidal activity of the methanol extract and fractions of Abrus precatorius seeds in ***:Parasiteamia was induced unto mice by intraperitoneal injection of 1.25×105 Trypanosoma in normal *** days when a high level of parasiteamia was established treatment commenced until ten *** mice were treated with 10,20 and 40 mg/kg *** the extract and 5 and 10 mg/kg *** the fraction（F2）,respectively for 5 *** acelurate at the dose of 3.5 mg/kg *** two days was used as the reference *** level of parasitaemia and packed cell volume（PCV） of the animals estimated. Results:At doses of 10,20 and 40 mg/kg the crude extract showed a sharp reduction in the level of parasitaemia in mice compared with the untreated *** mice treated with F,at doses of 5 and 10 mg/kg showed a sharp reduction in the level of parasitamia to zero in day 9,and a gradual recovery from the 12th day of *** effect is comparable to that of the mice treated with 7 mg/kg of standard drug diminazene *** PCV of the treated showed a gradual decrease with time,but not as much as the untreated *** screening revealed the presence of glycosides,alkaloids,carbohydrates,tannins and proteins in the Abrus precatorius powder while F2 was rich in ***:This study shows that both the extract and the fractions of Abrus precatorius seeds exhibited a promising trypanocidal *** may be responsible for the observed activity.

关键词： Abrus precatorius Seed extract Trypanocidal effect Parasiteamia Fractions Trypanosome brucei brucei Berenil

Evaluation of phytochemical properties and in-vitro antibacterial activity of the aqueous extracts of leaf,seed and root of Abrus precatorius Linn. against Salmonella and Shigella

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2016年第9期6卷 755-759页

作者： Ojo Joseph Sunday Shola Kola Babatunde Adeyinka Elizabeth Ajiboye Racheal Majekodunmi Adedayo Mufutau Adeyemi Ajao Busayo Isreal Ajuwon Department of Biosciences and Biotechnology Kwara State University

Objective:To investigate the phytochemical components of Abrus precatorius(***) and the in-vitro susceptibility of Salmonella typhi and Shigella dysenteriae to the aqueous extracts of *** leaf,seed and ***:The leaf,seed and root of *** were collected and homogenized separately after drying at 40℃ for seven days in hot-air *** aqueous extracts of each of the parts were prepared and subjected to phytochemical *** of 400,300,200,100 mg/mL,of each of the extracts were used for broth dilution in minimum inhibitory concentration(MIC) determination against clinical isolates of Salmonella typhi and Shigella dysenteriae,while 50,40,30,20,and 10 mg/mL dilutions were used for the agar diffusion test and 100 mg/mL and 10 mg/mL of gentamycin were used as controls for broth dilution in MIC determination and agar diffusion test,***:Qualitative study reveals that tannin,saponins,alkaloids,flavonoids,terpenoids,steroids and phenols were present in all of the plant *** leaf has the highest quantities of tannin and *** root generally showed the lowest quantity of all the *** pathogens were susceptible to aqueous extracts of the leaf,stem and root of *** at 50 mg/*** concentrations of 40,30 and 20 mg/mL,all the aqueous extracts of *** showed variation in MIC,but produced no minimum bactericide effect upon *** were variations in diameter of zone of inhibition against the organisms at lower ***:These findings suggest that *** is a valuable source of phytochemicals with promising antibacterial *** this bioactivity,*** could be probed further for toxicity,and to obtain some novel antibacterial molecules.

关键词： Abrus precatorius Phytochemicals Antibacterial susceptibility Salmonella Shigella

Mast cell stabilizing and antiallergic activity of Abrus precatorius in the management of asthma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2011年第1期4卷 46-49页

作者： DJ Taur RY Patil Department of Pharmacognosy S.V.P.M's College of PharmacyMalegaon(bk)Baramati-413115MaharashtraIndia Department of Pharmacognosy PDEA's S.U.College of Pharmaceutical Sciences and Research CenterKharadiPune-411014MaharashtraIndia

Objective:To investigate effects of ethanol extract of Abrus precatorius leaves（EAPL） on egg albumin induced mast cell degranulation in mice and passive cutaneous anaphylaxis in rats. Methods:In present study ethanol extract of Abrus precatorius leaves（EAPL） at doses of 100,125, 150 mg/kg i.p were evaluated for preliminary phytochemical screening,acute toxicity studies and egg albumin induced mast cell degranulation in mice and passive cutaneous anaphylaxis in rats. Results:The results of present investigation showed that the LD50 of EAPL is more than 1300 mg/ ***（100-150 mg/kg,i.p.） significantly protect egg albumin induced degranulation of mast cell and inhibit area of leakage of dye in passive cutaneous *** studies observed presence of saponin,alkaloids,flavonoids,and ***:In conclusion EAPL possesses anti asthmatic potential.

关键词： Abrus precatorius Asthma Mast cell Allergy

Effect of extract of Abrus precatorius on blood glucose concentration of alloxan induced diabetic Albino Wistar Rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2009年第6期2卷 16-17页

作者： Georgewill OA Georgewill UO Department of Pharmacology and Toxicology

Objective:To evaluate the effect of extract of Abrus precatorius on blood glucose of alloxan induced albino wistar ***:Experimental animals received daily oral administration of extract of Abrus precatorius for 14 *** effect of 200 mg/kg dose was studied during the treatment ***:There was a significant reduction in blood glucose concentration(P precatorius has hypoglycemic effect.

关键词： Abrus precatorius Hypoglycemia Diabetes Hyperglycemia