Pathophysiological responses from human gut microbiome

作     者：Anindya Roy Chowdhury Utpal Bakshi 

作者机构：Structural Biology and Bioinformatics Division CSIR-Indian Institute of Chemical Biology 

出 版 物：《World Journal of Translational Medicine》 (世界转化医学杂志)

年 卷 期：2014年第3卷第3期

页      面：133-140页

学科分类：10[医学] 

基　　金：Supported by University Grants Commission(India)(Bakshi U) 

主　　题：Human gut microbiome Inflammatory bowel disease Colorectal cancer Obesity Autism 

摘      要：The human gastrointestinal tract harbors a vast collection of symbiotic microorganisms-collectively termed as gut microbiome. This microbiota has important effect in immune system and other host activities. Recent studies have suggested that alterations of the normal gut microbiota are associated with various human diseases and psychological disorders. The underlying cause, once proven, may provide novel insights into the importance of gut flora in human health. In this review, we give an attempt to describe how the alteration in the microbial community causes the development of certain widespread pathophysiological disorders; focusing on inflammatory bowel disease, colorectal cancer, obesity and autism. Proper knowledge about the hostmicrobiota interaction and linkage could be essential for the development of future personalized strategies of therapeutics.