New insights in sperm biology:How benchside results in the search for molecular markers may help understand male infertility
New insights in sperm biology:How benchside results in the search for molecular markers may help understand male infertility作者机构：Department of Experimental and Clinical Biomedical SciencesUniversity of Florence
出 版 物：《World Journal of Translational Medicine》 (世界转化医学杂志)
年 卷 期：2016年第5卷第1期
页 面：26-36页
学科分类：10[医学]
主 题：Sperm markers Male infertility Genetic and epigenetic approaches Proteomic approach Ion channels
摘 要：The male factor is responsible for about 40% of couple infertility cases and such percentage is expected to increase in the future because of several likely factors including the presence of endocrine disruptors in the environment,changes in lifestyle habits and advanced couple *** such factors affect male fertility status,however,should be *** studies on male fertility status have focused on parameters analyzed using a spermiogram test,the primary diagnostic tool in the routine assessment of male infertility,which is,however,poorly predictive of both natural and medically assisted *** these reasons it is mandatory for the scientific community to identify new molecular markers to incorporate into the existing diagnostic tests of male ***,such markers would be detected in mature spermatozoa to avoid invasive procedures for the *** review summarizes the recent advancements in benchside approaches that appear most promising for the development of new diagnostic sperm fertility tests,or identification of therapeutic targets,and,illustrates their advantages and limits.
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