检索结果-南通市图书馆

同方期刊数据库

Tandem pore TWIK-related potassium channels and neuroprotection

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第8期14卷 1293-1308页

作者： J.Antonio Lamas Diego Fernández-Fernández Laboratory of Neuroscience Biomedical Research Center (CINBIO) University of Vigo

TWIK-related potassium channels (TREK) belong to a subfamily of the two-pore domain potassium channels family with three members, TREK1, TREK2 and TWIK-related arachidonic acid-activated potassium channels. The two-pore domain potassium channels is the last big family of channels being discovered, therefore it is not surprising that most of the information we know about TREK channels predominantly comes from the study of heterologously expressed channels. Notw让hstanding, in this review we pay special attention to the limited amount of information available on native TREK-like channels and real neurons in relation to neuroprotection. Mainly we focus on the role of free fatty acids, lysophospholipids and other neuroprotective agents like riluzole in the modulation of TREK channels, emphasizing on how important this modulation may be for the development of new therapies against neuropathic pain, depression, schizophrenia, epilepsy, ischemia and cardiac complications.

关键词： TREK channels TREK-1 TREK-2 TRAAK neuroprotection free fatty acids lysophospholipids riluzole

Potassium channels: A Potential Therapeutic Target for Parkinson's Disease

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2018年第2期34卷 341-348页

作者： Xiaoyan Chen Bao Xue Jun Wang Haixia Liu Limin Shi Junxia Xie Collaborative Innovation Center for Brain Science Department of Physiology Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders Key Laboratory of Pathogenesis and Prevention of Neurological Disorders Medical College of Qingdao University

The pathogenesis of the second major neurodegenerative disorder, Parkinson's disease(PD), is closely associated with the dysfunction of potassium(K^+ ) channels. Therefore, PD is also considered to be an ion channel disease or neuronal channelopathy. Mounting evidence has shown that K^+ channels play crucial roles in the regulations of neurotransmitter release, neuronal excitability, and cell volume. Inhibition of K^+ channels enhances the spontaneous firing frequency of nigral dopamine(DA)neurons, induces a transition from tonic firing to burst discharge, and promotes the release of DA in the striatum.Recently, three K^+ channels have been identified to protect DA neurons and to improve the motor and non-motor symptoms in PD animal models: small conductance(SK)channels, A-type K^+ channels, and KV7/KCNQ channels.In this review, we summarize the physiological and pharmacological effects of the three K^+ channels. We also describe in detail the laboratory investigations regarding K^+ channels as a potential therapeutic target for PD.

关键词： Parkinson's disease A-type K+ channels SKchannels - Kv7/KCNQ channels Dopamine

在线全文

学校读者我要写书评

暂无评论

channels的选择

现代装饰（家居） 2013年第6期 21-22页

作者：陈雅男 Samuel Chan 肖俊 channels

"作为一名设计师,我觉得最重要的就是能让我感到他们是了解我们的产品,欣赏它的价值,懂得怎么去跟客户沟通和介绍我们,同时对全球行业状态以及当代设计界所发生的一切有一个大概的了解。"——Samuel Chan channels品牌为Samuel Chan陈... 详细信息

"作为一名设计师,我觉得最重要的就是能让我感到他们是了解我们的产品,欣赏它的价值,懂得怎么去跟客户沟通和介绍我们,同时对全球行业状态以及当代设计界所发生的一切有一个大概的了解。"——Samuel Chan channels品牌为Samuel Chan陈维正先生于1995年创办。工作室位于伦敦西南部。为了更好地控制设计、生产到销售的全部过程,工作室带有展厅,同时还配备一间位于Shropshire的工厂,力图呈现现代化的设计理念及完备的生产工艺。

关键词：客户沟通当代设计维正 channels 生产工艺做事方式创办人木工工艺二字产品设计

Role of TRP channels and HSPs in thermal stress response in the aphid parasitoid Aphelinus asychis(Hymenoptera:Aphelinidae)

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2020年第6期19卷 1530-1542页

作者： LIU Xiang KANG Zhi-wei YU Xing-lin LI Fan LIU Tong-xian LI Qiang Department of Entomology College of Plant ProtectionYunnan Agricultural UniversityKunming 650000P.R.China State Key Laboratory of Crop Stress Biology for Arid Areas/Key Laboratory of Northwest Loess Plateau Crop Pest Management of Ministry of Agriculture and Rural Affairs Northwest A&F UniversityYangling 712100P.R.China

Aphelinus asychis is an important aphid endoparasitoid.Under field and greenhouse conditions,high temperature is one of the factors limiting the application of A asychis for biological pest control.To explore the potential role of transient receptor potential(TRP)channels and heat shock proteins(HSPs)in this process,we identified 11 genes encoding TRP channels and nine genes encoding HSPs.Three proteins(AasyTRPA5,AasyPyrexia,AasyPainless)that belong to transient receptor potential ankyrin(TRPA)subfamily and nine HSPs are involved in the response to high temperature.We also investigated the survival of A asychis and the response of the identified TRP channels and HSPs to high temperature.The results showed that the maximum temperature that allowed A.asychis survival was approximately 41°C;females had higher survival rates than that of the males at 40 and 41°C.Short-term heat-shock resulted in increased expression of Amsysbsp in males,and Aasyhsp40,Aasyhsp68,Aasyhsp70-4,Aasyhsp70-5 and Aasyhsp90 were upregulated and then down regulated,whereas Aasyhsp70-3was upregulated at41°C.Moreover,Aasyhsp40and Aasyhsp90showed higherexpression levels in females,while Aasyshsp and Aasyhsp70-3 presented opposite expression patterns.At temperature above 35°C,expression of AasyPyrexia in females was significant higher than that in males,whereas AasyPainless mnd AasyTRPA5 presented higher expression in males at 40 and 41°C,respectively.Altogether,these results indicate that protect!on against thermal stress in A.asychis is coordinated by TRP channels and HSPs.These findings provide a basis for understanding the potential mechanism of A asychis in response to high temperatures.

关键词： Aphelinus asychis TRP channels heat-shock proteins thermal stress gene expression

Voltage-gated K^+channels promote BT-474 breast cancer cell migration

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2018年第6期30卷 613-622页

作者： Louis WC Chow Ka-Shun Cheng Kar-Lok Wong Yuk-Man Leung State Key Laboratory of Quality Research in Chinese Medicines Macao University of Science and TechnologyTaipaMacao 999078China UNIMED Medical Institute Hong Kong 999077China Organisation for Oncology and Translational Research Hong Kong 999077China Department of Anesthesiology China Medical University HospitalTaiehung 40447TaiwanChina Department of Anesthesiology the Qingdao University Yuhuangding HospitalYantai 264000China Department of Physiology China Medical UniversityTaichung 40402TaiwanChina

Objective: A variety of ion channels have been implicated in breast cancer proliferation and metastasis.Voltagegated K+(Kv) channels not only cause repolarization in excitable cells,but are also involved in multiple cellular functions in non-excitable cells.In this study we investigated the role of Kv channels in migration of BT474 breast cancer cells.Methods: Transwell technique was used to separate migratory cells from non-migratory ones and these two groups of cells were subject to electrophysiological examinations and microfluorimetric measurements for cytosolic Ca^(2+).Cell migration was examined in the absence or presence of Kv channel blockers.Results: When compared with non-migratory cells,migratory cells had much higher Kv current densities,but rather unexpectedly,more depolarized membrane potential and reduced Ca^(2+) influx.Reverse transcriptasepolymerase chain reaction(RT-PCR) analysis revealed the presence of Kv1.1,Kv1.3,Kv1.5,Kv2.1,Kv3.3,Kv3.4 and Kv4.3 channels.Cell migration was markedly inhibited by tetraethylammonium(TEA),a delayed rectifier Kv channel blocker,but not by 4-aminopyridine,an A-type Kv channel blocker.Conclusions: Taken together,our results show that increased Kv channel expression played a role in BT474 cell migration,and Kv channels could be considered as biomarkers or potential therapeutic targets for breast cancer metastasis.The mechanism(s) by which Kv channels enhanced migration appeared unrelated to membrane hyperpolarization and Ca^(2+) influx.

关键词： Breast cancer Kv channels migration biomarkers

Buried channels provide keys to infer Quaternary stratigraphic and paleo-environmental changes:A case study from the west coast of India

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2019年第4期10卷 1577-1595页

作者： K.M. Dubey A.K.Chaubey V.P. Mahale S.M. Karisiddaiah CSIR-National Institute of Oceanography Dona PaulaGoa403004India CSIR-National Institute of Oceanography Regional CentreLokhandwala RoadAndheri (West)MumbaiMaharashtra400053India Department of Marine Sciences Goa UniversityTaleigao PlateauGoa403206India

High resolution shallow seismic data was acquired from inner continental shelf of Goa,west coast of India to map underlying stratigraphic and buried geomorphic features of shelf strata.Seismic data revealed characteristic channel incisions beneath 4-15 m thick sediment layer and corresponds to multi cycle incisions.Stratigraphic analysis of these incision signatures reveals three prominent subaerial unconformities S6,S7 and S9.These unconformities were exposed during the last glacial,penultimate glacial(MIS-6)and prior to penultimate glacial(MIS-8)periods.On the basis of interpreted age of subaerial unconformities and differences in their morphological features,observed channel incisions have been divided grossly into three phases of incision.Phase-1 incisions are older than^330 kyr BP,whereas,incisions of Phase-2 and Phase-3 correspond to^320-125 kyr BP and^115-10 kyr BP respectively.Plan form of these incisions varied from a straight channel type to ingrown meander and then to anastomosing channel types.These channels meet at the confluence of present-day Mandovi and Zuari rivers.The confluence point has varied in due course of time because of cyclic incision and burial with repeated sea level fluctuations.The preserved main channel width varies from^100 m to 1000 m.and maximum channel depth reaches up to^35 m.Comparison of quantitative and qualitative morphologic results of different phases of incisions suggest that Phase-2 channels had^33%more mean bank full discharge than that of the Phase-3 channels.Phase-2 incisions had been carved in higher hydraulic energy condition as compared to Phase-3 incisions implying that the Indian summer monsoon was better during formative stages of Phase-2 incisions.

关键词： Buried channels Glacial period Indian summer monsoon Quaternary sea-level Subaerial unconformity West coast of India

Experiment on Boiling Heat Transfer of Refrigerant R134a in Mini-channels

在线全文

学校读者我要写书评

暂无评论

Transactions of Nanjing University of Aeronautics and Astronautics 2019年第1期36卷 80-87页

作者： ZHAN Hongbo SHEN Hao WEN Tao ZHANG Dalin College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics Shanghai Aircraft Airworthiness Certification Center of CAAC

The flow boiling heat transfer characteristics of refrigerant R134 a flowing inside two different kinds of minichannels are investigated. One channel is multi-port extruded with the hydraulic diameter of 0.63 mm,and the other one is rectangular with offset fins and a hydraulic diameter of 1.28 mm. The experiments are performed with a mass flow rate between 68 and 630 kg/(m^2·s),a heat flux between 9 and 64 kW/m^2,and a saturation pressure between 0.24 and 0.63 MPa,under the constant heat flux heating mode. It is found that the effect of mass flow rate on boiling heat transfer is related to heat flux,and that with the increase of heat flux,the effect can only be efficient in higher vapor quality region. The effects of heat flux and saturation pressure on boiling heat transfer are related to a threshold vapor quality,and the value will gradually decrease with the increase of heat flux or saturation pressure. Based on these analyses,a new correlation is proposed to predict the boiling heat transfer coefficient of refrigerant R134 a in the mini-channels under the experimental conditions.

关键词： flow boiling heat transfer two-phase flow refrigerant R134a channels with offset fins multi-portchannel

Robust and Efficient Data Transmission over Noisy Communication channels Using Stacked and Denoising Autoencoders

在线全文

学校读者我要写书评

暂无评论

China Communications 2019年第8期16卷 82-92页

作者： Faisal Nadeem Khan Alan Pak Tao Lau Department of Electrical Engineering The Hong Kong Polytechnic University

We study the effects of quantization and additive white Gaussian noise(AWGN) in transmitting latent representations of images over a noisy communication channel. The latent representations are obtained using autoencoders(AEs). We analyze image reconstruction and classification performance for different channel noise powers, latent vector sizes, and number of quantization bits used for the latent variables as well as AEs’ parameters. The results show that the digital transmission of latent representations using conventional AEs alone is extremely vulnerable to channel noise and quantization effects. We then propose a combination of basic AE and a denoising autoencoder(DAE) to denoise the corrupted latent vectors at the receiver. This approach demonstrates robustness against channel noise and quantization effects and enables a significant improvement in image reconstruction and classification performance particularly in adverse scenarios with high noise powers and significant quantization effects.

关键词： communication channels data compression deep learning autoencoders denoising autoencoders

Aetiology of bipolar disorder: contribution of the L-type voltage-gated calcium channels

在线全文

学校读者我要写书评

暂无评论

General Psychiatry 2019年第3期32卷 152-154页

作者： Xiaoyun Guo Dengtang Liu Tong Wang Xingguang Luo Department of psychiatry Shanghai Mental Health Center Shanghai China Department of Cellular and Molecular Physiology Yale University School of Medicine New Haven Connecticut USA Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA

LTCCS ARE IMPLICATED IN THE PATHOLOGY OF BIPOLAR DISORDER Bipolar disorder (BPD) is a common mental illness with significant morbidity and mortality.1 Although evidence have suggested changes in oxidative stress, dopamine and inflammation in BPD, it is hard to define the aetiological mechanism of BPD clearly. Recently, some but not all candidate gene association studies, family-based association studies, linkage studies, genome-wide association studies (GWASs) and meta-analyses showed that mutation of L-type voltage-gated calcium chan? nels (LTCCs) gene CACNAlCis implicated in the mechanism of BPD.'-8 These findings support the possibility that BPD might have calcium channelopathy.

关键词： Aetiology of bipolar disorder contribution calcium channels