Systematic review of the non surgical management of Peyronie's disease
Systematic review of the non surgical management of Peyronie's disease作者机构：Department of Neuroscience Reproductive Sciences and Odontostomatology Urology Unit University of Naples Federico Ⅱ National Centre of Urology
出 版 物：《World Journal of Clinical Urology》 (世界临床泌尿杂志)
年 卷 期：2014年第3卷第1期
页 面：31-37页
学科分类：10[医学]
主 题：Peyronie’s disease Non surgical Dupuytren Extracorporeal shockwave therapy
摘 要：This systematic review shows the Status quo on medical treatment for Peyronie s disease(PD). PD is a connective tissue disorder, characterised by the formation of a fibrotic lesion or plaque in the tunica albuginea, which leads to penile deformity. The aetiology of PD is unknown. Nowadays the most widely accepted hypothesis proposed by Gonzalez-Cadavid et al, is repetitive microvascular injury or trauma to the tunica albuginea. Physicians have proposed several medical alternatives for treatment of this disease with few effective results. Nevertheless, as of today nonsurgical options are currently available, and some of them are able to stabilize or even reduce deformity while improving pain relief and sexual function. A systematic literature search throughout the Medline database was carried out. Thecontrolled vocabulary of the medical subject headings database employs the specific term penile induratio for PD. A total of 50 articles on PD were found. Studies were selected based on clinical relevance. The recommended standard of care for PD involves an initial treatment in the acute phase. Several non-operative treatment options have been used. Unfortunately no further substantial, quality evidence on the use of medical therapy currently exits. There is, however, an increasingly enhanced interest in this disorder and basic scientifi c and clinical research will eventually lead to a more effective methodology to study the disease.
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