Vitamin D deficiency and hepatitis viruses-associated liver diseases:a literature review

作     者：Nghiem Xuan Hoan Hoang Van Tong Le Huu Song Christian G Meyer Thirumalaisamy P Velavan 

作者机构：Institute of Clinical Infectious Diseases108 Military Central HospitalHanoi 10004Vietnam Molecular Genetics of Infectious DiseasesInstitute of Tropical MedicineUniversity of TübingenTübingen 72074Germany Vietnamese-German Center of Medical Research(VG-CARE)Hanoi 10004Vietnam Institute of Biomedicine and PharmacyVietnam Military Medical UniversityHanoi 10004Vietnam Medical FacultyDuy Tan UniversityDa NangVietnam 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2018年第24卷第4期

页      面：445-460页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：financial support from Vietnam National Foundation for Science and Technology Development(NAFOSTED)under grant number 108.02-2017.15 Thirumalaisamy P Velavan acknowledges the support from Federal Ministry of Edu-cation and Research,Germany(BMBF01DP17047) 

主　　题：Vitamin D vitamin D deficiency chronic liver disease hepatitis B virus infection hepatitis C virus infection liver cirrhosis hepatocellular carcinoma sustained virological response vitamin D supplementation 

摘      要：The secosteroid hormone vitamin D has, in addition to its effects in bone metabolism also functions in the modulation of immune responses against infectious agents and in inhibiting tumorigenesis. Thus, deficiency of vitamin D is associated with several malignancies, but also with a plethora of infectious diseases. Among other communicable diseases, vitamin D deficiency is involved in the pathogenesis of chronic liver diseases caused by hepatitis B and C viruses(HBV, HCV) and high prevalence of vitamin D deficiency with serum levels below 20 mg/mL in patients with HBV and HCV infection are found worldwide. Several studies have assessed the effects of vitamin D supplementation on the sustained virological response(SVR) to interferon(IFN) plus ribavirin(RBV) therapy in HBV and HCV infection. In these studies, inconsistent results were reported. This review addresses general aspects of vitamin D deficiency and, in particular, the significance of vitamin D hypovitaminosis in the outcome of HBVand HCV-related chronic liver diseases. Furthermore,current literature was reviewed in order to understand the effects of vitamin D supplementation in combination with IFN-based therapy on the virological response in HBV and HCV infected patients.