Evaluation of wound healing and antimicrobial potentials of Ixora coccinea root extract

作     者：Nagaraj Selvaraj Baskar Lakshmanan Papiya Mitra Mazumder Muthukumar Karuppasamy Simon Santosh Jena Ashok Kumar Pattnaik 

作者机构：Department of Pharmaceutical SciencesBirla Institute of TechnologyMesraRanchiJharkhand-835215India 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2011年第4卷第12期

页      面：959-963页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Ixora coccinea Wound contraction Tensile strength Antimicrobial activity Ethanolic extract 

摘      要：Objective:To evaluate the wound healing and antimicrobial activity of root extracts of Ixora coccinea(***).Methods:To investigate the wound healing efficacy of root extract of *** Linn,five groups of animals were divided each containing six *** wound models including incision and excision wound models were used in this *** parameters studied were tensile strength on incision wound model and in terms of wound contraction for excision wound model were compared with standard Nitrofurazone(NFZ) ointment(0.2%w/w). Six extracts(***,petroleum ether,benzene,chloroform and ethyl acetate ) of I. coccinea were screened for in vitro growth inhibiting activity against different bacterial strains riz. Staphylococcia *** pumilius,Enterococcus *** coli,Salmonella typhi and Pseudomonas aeruginosa and fungi Candida albicans and Aspergillus niger were compared with the standard drugs ciprofloxacin and chloramphenicol for antibacterial and griscofulvin for antifungal *** serial dilution and cup(or) well plate methods were used for the antimicrobial study and MIC was ***:The ethanolic extract showed significant (P0.001) wound healing activity when compared to standard drug NFZ with respect to normal control *** *** extract showed highly significant antibacterial activity against all bacterial strains used in this study when compared to *** aqueous extract showed moderate significant inhibition against all bacterial strains when compared to standard. All the extracts were shown negligible activity against the fungal strains used in this study. Conclusions:The ethanolic root extract of *** showed pronounced wound healing and antibacterial *** probable reason to heal the wound was that the external application of the extract prevented the microbes to invade through the wound thus the protection of wound occurs against the infection of the various or