Functions of VEGF in female reproductive system

作     者：QIANDong ZHUCheng 

作者机构：StateKeyLaboratoryofReproductiveBiologyInstituteofZoologyChineseAcademyofSciencesBeijing100080China StateKeyLaboratoryofReproductiveBiologyInstituteofZoologyChineseAcademyofSciencesBeijing10008 

出 版 物：《Chinese Science Bulletin》 (CHINESE SCIENCE BULLETIN)

年 卷 期：2003年第48卷第3期

页      面：217-222页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 0905[农学-畜牧学] 09[农学] 090501[农学-动物遗传育种与繁殖] 

基　　金：supported by the State Key Basic Research Project(Grant No.1999055903) 2002 CAS Knowledge Innovation Progress 

主　　题：VEGF 血管内皮生长因子受体 雌性生殖系统 生物学作用 血管生成 生殖医学 

摘      要：As a homodimeric glycoprotein, vascular en- dothelial growth factor (VEGF) is a highly specific mitogen of vascular endothelial cells. It can induce proliferation and migration, and inhibit apoptosis of endothelial cell. VEGF is involved in many processes in the female reproductive sys-tem, such as ovulation, periodical changes of endometrium, embryo implantation and development. VEGF plays impor-tant roles in some reproductive diseases, including pree-clampsia and fetal hypoevolutism in uterus. Based on our studies on angiogenesis and its relevant factors in the female reproductive system these years, the functions of VEGF in female reproductive system are reviewed, and the research prospect and application of VEGF are also discussed.