The Effect of the Hot Water Extracts of the <i>Paecilomyces hepiali </i>and <i>Cordyceps militaris</i>Mycelia on the Growth of Gastrointestinal Bacteria

作     者：Sanath Gamage Jiro Nakayama Yusuke Fuyuno Shoji Ohga 

作者机构：Department of Agro-Environmental Sciences Faculty of Agriculture Kyushu University Fukuoka Japan Department of Bioscience and Biotechnology Faculty of Agriculture Kyushu University Fukuoka Japan 

出 版 物：《Advances in Microbiology》 (微生物学（英文）)

年 卷 期：2018年第8卷第7期

页      面：490-505页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Ophiocordyceps sinensis Cordyceps militaris Antibacterial Activity Human Gut Bacteria 

摘      要：The gastrointestinal health is very important aspect concerning human health. It refers to nutrient and vitamin absorption, food digestion and various infectious diseases. The Paecilomyces hepiali and Cordyceps militaris are highly enriched with cordycepin and ergosterol which are considered as anti bacterial substances. Present study finds out comparative effect of hot water extract of particular fungal material on growth of six species of gastrointestinal bacteria that belong to both aerobic and anaerobic and, consist with harmful and commensal categories. The appropriate concentration level of hot water extract of both strains was identified. The individual specific bacterial growing media were prepared and calculated;amounts of bacteria cultures were inoculated by using micro pipettes. The optical density and number of bacterial colonies were measured after 24 hours. The pure mycelial extract of P. hepiali with 2 × 10-3 g/ml of concentration has significant effect on depleting the growth of E. coli, E. faecalis, S. aureus, L. gasseri and B. ovatus bacteria. B. longum has no significant effect by particular extract. Same type of extract of C. militaris has significantly reduced the growth of every bacteria used in this study. Hot water extract of C. militaris cultivated on soy bean has significant growth retardation toward E. coli, E. faecalis, S. aureus and L. gasseri. It has stimulated the growth of B. ovatus and B. longum which are considered as beneficial bacteria for human gut. This study shows that extracts of both mycelia include antimicrobial substances like cordycepin and ergosterol which can be used as food supplements to enhance human gut health.