Progress in study of structure-function relationship and protein engineering of plasminogen activators

作     者：Fuxiang Zhu Fuchu He 

作者机构：Beijing Inst Radiat Med Beijing 100850 Peoples R China 

出 版 物：《Chinese Science Bulletin》 (科学通报(英文版))

年 卷 期：1999年第44卷第4期

页      面：289-294页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：National Natural Science Foundation of China NSFC: 39730310 

主　　题：thrombolytic agents t-PA u-PA variants. 

摘      要：Thrombolytic agents play an important role in the treatment of thrombus diseases. In clinic,traditional thrombolytic agents always resulted in the side effect of systemic thrombolysis because of the shortcomings, such as short half-life, poor specificity of thrombus. Recently, with the development of knowledge of the relationship between their structure and function, a series of new thrombolytic agents were constructed by means of molecular biological techniques. Developing new types of thrombolytic agents is of great significance for more effective treatment of cardiovascular diseases. The latest knowledge of the structure-function relationship of t-PA and u-PA and the progress in development of new thrombolytic agents are reviewed.