Malaria parasitaemia and disorders of plasma electrolytes

作     者：Idogun ES Airauhi LU 

作者机构：Department of Chemical PathologyUniversity of Benin Teaching HospitalBenincityEdo-StateNigeria Department of Medical MicrobiologyUniversity of Benin Teaching HospitalBenincityEdo-StateNigeria 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2009年第2卷第5期

页      面：34-37页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Malaria Parasitaemia Plasma electrolytes Disorders 

摘      要：Objective:To assess the plasma electrolyte status of patients with diagnosis of malaria but without the symptoms of diarrhea,vomiting or altered sensorium and correlation of the plasma electrolyte changes and the degree of parasitaemia. Methods:All the participants were adults,who met the clinical case definition of malaria but without the symptoms of diarrhea,vomiting or other medical *** slides were screened microscopically for malaria parasite and the parasite positive patients were grouped into A(mild),B(moderate) and C(heavy) malaria parasiteamia, depending on the malaria parasite count per high power microscopic *** sodium,potassium and chloride were estimated using the ion selective electrode method,while bicarbonate ions were determined by simple titration ***:A total of 200 subjects were studied which comprised of 150 patients and 50 *** mean plasma sodium was significantly lower in patients with heavy parasitaemia[group C,(128.8±1.2) mmol/L] compared to those with mild and moderate parasitemia[(133.5±2.8) mmol/L and(133.5±3.5) mmol/L,P0.0001].The mean plasma chloride was lowest in those patients with heavy parasitaemia(group C) than those patients of group A and B(P0.0001).Patients in group C also had significant hypokalaemia[(3.2±0.5) mmol/ L]when compared to those in groups A and B[(3.6±0.3) mmol/L and(4.1±0.6) mmol/L respectively,P0. 0001].Conclusion:A disorder of plasma electrolytes in malaria patients that had no symptoms of diarrhea and vomiting was *** the severity of hyponatraemia and hypokalaemia correlate with the severity of the patients’ malaria *** data should alert clinicians on the need to assess electrolytes status of patients with malaria even without the symptoms of fluid loss,especially when malaria parasitaemia is heavy.