窄波UVB光线疗法对泛发性扁平苔癣的治疗
Narrowband UVB phototherapy in the treatment of widespread lichen planus (Fren)作者机构:Service de Dermatologie Grp. Hosp.-Universitaire Caremeau 30900 Nmes France
出 版 物:《世界核心医学期刊文摘(皮肤病学分册)》 (Digest of the World Core Medical JOurnals:Dermatology)
年 卷 期:2005年第1卷第6期
页 面:45-46页
学科分类:1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学]
主 题:光线疗法 UVB 扁平苔癣 泛发性 银屑病 无反应型 播散性 皮肤面积 教学医院 复发率
摘 要:Introduction. UVA phototherapy, acitretin and oral corticosteroids are currently the front-line treatment of disseminated cutaneous lichen planus. We studied the efficacy of narrowband UVB therapy in this indication. Patients and methods. We retrospectively studied the dossiers of patients suffering from disseminated cutaneous lichen planus, treated with narrowband phototherapy in the Phototherapy Unit of the University hospital in Montpellier, from May to November of the year 2001. Disseminated lichen planus was defined as lichen involving at least 20p. 100 of the skin surface. Twenty patients were included. UVB were applied thrice weekly using a Philips TL01 cubicle (311313 nm). The protocol was that used for the treatment of psoriasis. We defined 4 types of response: complete response (disappearance of more than 90p. 100 of the lesions), partial response (disappearance of at least 50p. 100) poor response (improvement in 20 to 50p. 100) and failure (less than 20p. 100 reduction in the lesions). Assessment of relapses in the long term was made using a telephone survey among the patients treated or their physicians. Results. Complete response was obtained in 11 out of the 20 patients (55p. 100) and partial response in 4 (20p. 100), corresponding to 75p. 100 of the responders. Response was obtained with a median delay of 3 months, ranging from 2 to 6 months, following a median of 30 sessions (12 to 50) and acumulated dose of UVB of 36± 4.8 joules/cm2. The phototype, gender, age and duration of evolution before treatment did not influence the response. The relapse rate was and estimated 18p. 100 (2/11) 42 months after treatment had been stopped. Discussion. In our opinion, these results underline the efficacy of narrowband UVB in the treatment of disseminated cutaneous lichen planus. They confirm those of earlier studies and are superimposable with those of oral UVA phototherapy.