肉芝软珊瑚Sarcophyton crassocaule中新的多羟基甾醇的分离
Isolation of New Polyhydroxylated Sterol from Soft Coral Sarcophyton crassocaule Mosre作者机构：中山大学化学与化工学院 广州中医药大学中药学院广州510405 暨南大学食品科学与工程系
出 版 物：《高等学校化学学报》 (Chemical Journal of Chinese Universities)
年 卷 期：2007年第28卷第4期
页 面：686-688页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：国家自然科学基金(批准号:29932030) 国家'八六三'计划项目(批准号:2001AA620403)资助
摘 要：In our continuing search of discovering bioactive substances from marine organisms, a sample of soft coral Sarcophyton crassocaule Mosre collected off the Sanya bay, China, was investigated. Two polyhydroxylated sterols 1 and 2 were isolated from the 95% ethanol extract of the sample by chromatography over silica gel. Compound 1, named sarcrasterol, was a new compound, its structure was established as(22R*,24ξ)-methyl-cholest-5-en-3β,22α,25,28-tetraol by spectroscopic methods. Compound 2, a known compound, was first obtained by Kobayashi, however, the relative configuration of C24 has not been determined yet. This paper reports the stereochemistry of compound 2 established as (24S*)-methyl cholest-3β,5β,6α,25-tetraol by means of X-ray single crystal diffraction analysis. Bioassay results show that compound 2 has a moderate activity against human tumor cell lines MGC-803 with an IC50 value of 23.0 μg/mL.
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