Alterations in hepatic metabolism of adult male rats following exposure to hydroxyprogesterone during embryonic development

作     者：T.Pushpalatha P.RamachandraReddy P.SreenivasulaReddy 

作者机构：Department of Biotechnology Sri Venkateswara UniversityTirupati 517502India 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2006年第8卷第4期

页      面：463-467,516-517页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学] 

主　　题：hydroxyprogesterone liver oxidative enzymes antioxidants lipid peroxidation embryonic development 

摘      要：Aim:To investigate the effect of in utero exposure to hydroxyprogesterone(HP)on liver metabolism in adult male albino ***:Pregnant Wistar strain albino rats were exposed to supra-normal levels(10 mg/kg and 25 mg/kg)of HP on days 1,7 and 14 of *** male pups were maintained under controlled conditions and the rats were killed 90 days after *** liver tissue was immediately excised,weighed and used for biochemical assays. Results:The activity levels of succinate dehydrogenase(SDH),glutamate dehydrogenase(GDH),glucose-6-phosphate dehydrogenase(G-6-PDH),malate dehydrogenase(MDH)and aminotransaminases were significantly increased in the livers of rats exposed to HP during embryonic *** lactate dehydrogenase(LDH)activity level was significantly decreased in the liver of experimental ***,there was a significant elevation of activity levels of antioxidant enzymes(glutathione S-transferase[GST] and catalase[CAT])with an increased lipid peroxidation in the hepatic tissue of experimental rats compared with the control ***:The results of the present study suggest that there is an increase in the oxidative metabolism,antioxidative mechanism and levels of lipid peroxidation in rats exposed to HP during embryonic *** increased aminotransaminase activities in these rats reveal tissue damage and disruption of mitochondrial integrity.(Asian J Androl 2006 Jul;8:463-467)