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hydroxyprogesterone caproate for preterm birth:A situational analysis from the Indian perspective

Gynecology and Obstetrics Clinical Medicine 2021年第3期1卷 144-147页

作者： Pugazhenthan Thangaraju Shoban Babu Varthya Prakash Srinivasan Timiri Shanmugam T.Y.Sree Sudha Chaitanya Mittal Department of Pharmacology All India Institute of Medical SciencesRaipurChhattisgarhIndia Department of Pharmacology All India Institute of Medical SciencesJodhpurRajasthanIndia Global Product Safety&Toxicology Avanos Medical IncAlpharettaGAUSA Forensic Toxicology All India Institute of Medical SciencesJodhpurRajasthanIndia

Background:Preterm birth can cause morbidity and mortality in addition to trauma or loss to the mother,and present a major financial burden to the *** risk may be minimized by timely ***:To understand the safety and efficacy of hydroxyprogesterone in decreasing the incidence of preterm birth,neonatal complications,and maternal mortality,based on evidence obtained from the Indian scientific ***:Relevant articles were searched for and retrieved from the databases PubMed,medrXiv,Embase,Cochrane,biorXiv,and ***:A total of 62 relevant articles were assessed,and of these,59 articles did not meet the eligibility *** total,3 articles which satisfied the criteria and 2 articles sourced from cross references were included in the *** these 5 articles,a total of 536 patients received hydroxyprogesterone caproate or placebo for preterm ***:In all five articles,recurrence rate of preterm birth was reduced in the treated group compared to control *** safety profile of progesterone tends to be better than that of the *** findings of our analysis of individual patient data(IPD)summarizes various clinical trial data,which can assure clinicians that vaginal progesterone administration is effective and well tolerated.

关键词： Preterm birth hydroxyprogesterone India

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Alterations in hepatic metabolism of adult male rats following exposure to hydroxyprogesterone during embryonic development

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Asian Journal of Andrology 2006年第4期8卷 463-467,516-517页

作者： T.Pushpalatha P.RamachandraReddy P.SreenivasulaReddy Department of Biotechnology Sri Venkateswara University Tirupati 517502India

Aim:To investigate the effect of in utero exposure to hydroxyprogesterone(HP)on liver metabolism in adult male albino ***:Pregnant Wistar strain albino rats were exposed to supra-normal levels(10 mg/kg and 25 mg/kg)of HP on days 1,7 and 14 of *** male pups were maintained under controlled conditions and the rats were killed 90 days after *** liver tissue was immediately excised,weighed and used for biochemical assays. Results:The activity levels of succinate dehydrogenase(SDH),glutamate dehydrogenase(GDH),glucose-6-phosphate dehydrogenase(G-6-PDH),malate dehydrogenase(MDH)and aminotransaminases were significantly increased in the livers of rats exposed to HP during embryonic *** lactate dehydrogenase(LDH)activity level was significantly decreased in the liver of experimental ***,there was a significant elevation of activity levels of antioxidant enzymes(glutathione S-transferase[GST] and catalase[CAT])with an increased lipid peroxidation in the hepatic tissue of experimental rats compared with the control ***:The results of the present study suggest that there is an increase in the oxidative metabolism,antioxidative mechanism and levels of lipid peroxidation in rats exposed to HP during embryonic *** increased aminotransaminase activities in these rats reveal tissue damage and disruption of mitochondrial integrity.(Asian J Androl 2006 Jul;8:463-467)

关键词： hydroxyprogesterone liver oxidative enzymes antioxidants lipid peroxidation embryonic development

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EXPERIMENTAL STUDIES ON THE LATE EFFECTS OF FEMALE SEX HORMONES

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Science China Chemistry 1990年第3期33卷 311-322页

作者：高凤鸣蒋涵英于雁南李新兰王文惠 Laboratory of Industrial Hygiene Ministry of Public Health Beijing 100088 PRC

Inj. hydroxyprogesterone Co. (EP) was injected i.m. into female Wistar rats, different strains of mice of both sex and Syrian golden hamsters with doses of 5--100 times the human contraceptive dose once or twice a month for 10--32 times. In some experiments EP was combined with whole-body 3 Gy gamma ray radiation once or twice. Results show that EP has obvious carcinogenicity and can enhance the gamma ray carcinogenicity, thereby increasing the tumor incidence or the ratio of malignant to benign turnouts. Carcinogenic mechanisms of EP have also been studied.

关键词： estradiol valerate hydroxyprogesterone eaproate carcinogenesis neoplastic transformation gamma rays.

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