Sepsis biomarkers： an omics perspective

作     者：Xiao Liu Hui Ren Daizhi Peng 

作者机构：Institute of Burn Research Southwest Hospital State Key Laboratory of Trauma Burns and Combined Injury Third Military Medical University Chongqing 400038 China School of Nursing Third Military Medical University Chongqing 400038 China 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2014年第8卷第1期

页      面：58-67页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 081803[工学-地质工程] 07[理学] 08[工学] 0817[工学-化学工程与技术] 0818[工学-地质资源与地质工程] 

基　　金：supported by grants from the Supporting Program for Science and Technology Research of China Medical Project of the Ministry of Health of China the Open Program Fund of State Key Laboratory of Trauma, Burns, and Combined Injury 

主　　题：sepsis biomarker genomics transcriptomics proteomics metabolomics 

摘      要：Sepsis is a common cause of death in hospitalized patients worldwide. The early detection of sepsis remains a great challenge for clinicians, and delayed diagnosis frequently undermines treatment efforts, thereby contributing to high mortality. Omics technologies allow high-throughput screening of sepsis biomarkers. This review describes currently available and novel sepsis biomarkers in the context of genomics, transcriptomics, proteomics, and metabolomics. The combination of these technologies can help refine the diagnosis of sepsis. This review paper serves as a reference for future studies that employ an integrated, multi-omics approach to disease identification.