Effect of orthodontic force on inflammatory periodontal tissue remodeling and expression of IL-6 and IL-8 in rats

作     者：Jian-Hao Yang Zheng-Chen Li Wei-Dong Kong Wu Zhang Ying-Ping Jia Yue-Lan Zhang Lin-Bo Liu Xue-Ping Han 

作者机构：Department of StomatologyFirst Affiliated Hospital of Zhengzhou University Stomatological Medical College of Zhengzhou UniversityZhongyuan RoadZhengzhou City Department of AnesthesiaFirst Affiliated Hospital of Zhengzhou University Children's Hospital of ZhengzhouZhengzhou City Department of StomatologyFirst Affiliated Hospital of Jinan University Children's Hospital of Zhengzhou Stomatological Medical College of Zhengzhou University Department of Plastic and CosmetologyFirst Affiliated Hospital of Zhengzhou University 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2013年第6卷第10期

页      面：757-761页

核心收录：

学科分类：1003[医学-口腔医学] 100302[医学-口腔临床医学] 10[医学] 

基　　金：supported by Department of Science and Technology in Henan Province(No 122300410407) 

主　　题：Orthodontic tooth movement Inflammatory periodontal tissue Interleukin-6 Interleukin-8 

摘      要：Objective:To investigate effect of orthodontic force on inflammatory periodontal tissue remodeling and expression of IL-6 and IL-8 in ***:Eighty SD rats were randomly divided into 4 groups,blank control group(group A)with 5 rats,treatment normal group(group B)with 25 rats,inflammation control group(group(group C)with 25 rats,inflammation treatment group(group D)with 25 *** and histomorphometric analysis was performed to measure the expression of IL-6,IL-8 and the firet molar to the recent movement in the ***:The expression of IL-8 reached a maximum on day 5 and declined thereafter in group B;the expression of IL-6 reached a maximum on day 5 in group *** expression of IL-6 and IL-8 was gradually weakened with time in group *** expression of IL-6 and IL-8 were high,and reached a maximum on day 5 and declined thereafter in group *** of positive cells in group D were higher than group B at each time point(P0.05).The time which 0.49 N orthodontic force was loaded was longer,orthodontic tooth movement distance was *** distance in group D were longer than group B(P0.05).Conclusions:Orthodontic force as well as inflammatory stimulus can evoke the expression of IL-6 and *** the combined effects of inflammation and orthodontic force,the expression of IL-6,IL-8will increase.