Shrink-induced graphene sensor for alpha-fetoprotein detection with low-cost self-assembly and label-free assay

作     者：Shota SANDO Bo ZHANG Tianhong CUI 

作者机构：Department of Mechanical Engineering University of MinnesotaMinneapolis MN 55455 USA 

出 版 物：《Frontiers of Mechanical Engineering》 (机械工程前沿（英文版）)

年 卷 期：2017年第12卷第4期

页      面：574-580页

核心收录：

学科分类：1002[医学-临床医学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 100205[医学-精神病与精神卫生学] 10[医学] 

主　　题：graphene self-assembly shrink polymer,AFP label-free biosensor 

摘      要：Combination of shrink induced nano-compo- sites technique and layer-by-layer （LbL） self-assembled graphene challenges controlling surface morphology. Adjusting shrink temperature achieves tunability on graphene surface morphology on shape memory polymers, and it promises to be an alternative in fields of high- surface-area conductors and molecular detection. In this study, self-assembled graphene on a shrink polymer substrate exhibits nanowrinkles after heating. Induced nanowrinkles on graphene with different shrink tempera- ture shows distinct surface roughness and wettability. As a result, it becomes more hydrophilic with higher shrink temperatures. The tunable wettability promises to be utilized in, for example, microfluidic devices. The graphene on shrink polymer also exhibits capability of being used in sensing applications for pH and alpha- fetoprotein （AFP） detection with advantages of label free and low cost, due to self-assembly technique, easy functionalization, and antigen-antibody reaction on gra- phene surface. The detection limit of AFP detection is down to 1 pg/mL, and therefore the sensor also has a significant potential for biosensing as it relies on low-cost self-assembly and label-free assay.