Novel triterpene saponins isolated from Clematis mandshurica and their inhibitory activities on NO production

作     者：FU Qiang YANG Min MA Yu CHEN Jiang YUAN Hai-Mei 

作者机构：College of Pharmacy and Biological Engineering Chengdu University 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2018年第16卷第2期

页      面：131-138页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.81503234) 

主　　题：Clematis mandshurica Triterpene saponins Mandshunosides F—I NO production 

摘      要：Four new triterpene saponins, mandshunosides F–I(1–4), together with five known compounds(5–9), were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidences and hydrolysis products. Bisdesmosidic saponin(3–9) showed modest suppression of NO production with the inhibition ratios in the range of 51.3%– 64.6% at 50 μmol·L^(-1), whereas monodesmosidic saponins with a free carboxyl group at C-28(1 and 2) showed potent inhibitory activities with IC_(50) values being 12.7 and 8.3 μmol·L^(-1), respectively.