Clavuridins A and B, two new trinor-guaiane sesquiterpenes isolated from the Xisha soft coral Clavularia viridis

作     者：GAO Yuan XIAO Wei LIU Hong-Chun WANG Jian-Rong YAO Li-Gong OUYANG Ping-Kai WANG De-Cai GUO Yue-Wei 

作者机构：College of Biotechnology and Pharmaceutical Engineering Nanjing Tech University Nanjing 211816 China jiangsu Kanion Pharmaceutical Co. Ltd. Lianyungang 222002 China State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2017年第15卷第11期

页      面：855-859页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the Natural Science Foundation of China(Nos.81520108028,21672230,41506187,and 816013016) the SKLDR/SIMM Project(No.SIMM1501ZZ-03) 

主　　题：Soft coral Clavularia viridis Trinor-guaiane sesquiterpene Cytotoxic activity 

摘      要：In the present study, two new trinor-guaiane sesquiterpenes, named clavuridins B(1), and A(2), along with three known sesquiterpenes(3-5), were isolated from the Xisha soft coral Clavularia viridis. Their structures and absolute configurations were determined on the basis of spectroscopic analysis, X-ray diffraction analysis with Cu Kα radiation and by comparison with related model compounds. Compounds 1 and 3–5 were evaluated for their cytotoxic activity.