Nature:研究鉴定出蛋白Nlrp9b抵抗轮状病毒感染机制

作     者：Shu Zhu, Zheng Wei, Noah W. Palm, Yi Yang, Hua Yu, Hua-Bing Li, Geng Wang, Xuqiu Lei, Marcel R. de Zoete, Jun Zhao, Yunjiang Zheng, Haiwei Chen, Liang Shan, Richard A. Flavell Siyuan Ding, Ningguo Feng, Harry B. Greenberg Siyuan Ding, Harry B. Greenberg Penghua Wang, Yujiao Zhao Wen Pan, Jun Lu Jun Zhao, Yuval Kluger Kellie A. Jurado, Clara Abraham, Erol Fikrig Erol Fikrig, Richard A. Flavell 

作者机构：Department of Immunobiology Yale University School of Medicine New Haven Connecticut 06520 USA Department of Medicine and Department of Microbiology & Immunology Stanford University School of Medicine Stanford California 94305 USA Palo Alto Veterans Institute of Research VA Palo Alto Health Care System Palo Alto California 94304 USA Department of Microbiology and Immunology New York Medical College Valhalla New York 10595 USA Department of Genetics Yale University School of Medicine New Haven Connecticut 06520 USA Department of Pathology Yale University School of Medicine New Haven Connecticut 06520 USA Department of Internal Medicine Yale University School of Medicine New Haven Connecticut 06520 USA Howard Hughes Medical Institute Chevy Chase Maryland 20815 USA 

出 版 物：《现代生物医学进展》 (Progress in Modern Biomedicine)

年 卷 期：2017年第17卷第27期

页      面：I0002-I0002页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：Helen Hay Whitney Foundation-Howard Hughes Medical Institute VA Merit Review, (I01BX000158) Walter V. and Idun Berry Postdoctoral Fellowship National Institutes of Health, NIH, (R01AI021362, U19AI089992, U19AI116484) National Institutes of Health, NIH Thrasher Research Fund, TRF, (R01AI120369, R01DK099097, R01DK106593, R21AI103807) Thrasher Research Fund, TRF National Center for Advancing Translational Sciences, NCATS, (UL1TR001863) National Center for Advancing Translational Sciences, NCATS 

主　　题：感染机制 轮状病毒 蛋白 鉴定 肠上皮细胞 NF-KB 免疫系统 肠道粘膜 

摘      要：轮状病毒（rotavirus）是婴儿和儿童罹患肠胃炎和腹泻的一种最为常见的原因，每年导致全世界大约21．5万人死亡。它是高度传染性的和潜在致命性的。这种病毒特异性地感染宿主小肠中的肠上皮细胞，并且已进化出抵抗干扰素和NF-KB信号的策略来躲避免疫系统，这就提出一个问题：其他的宿主因子是否参与肠道粘膜中的抗病毒反应。不过，针对体内（特别是通过NLR炎性体）检测和限制肠道病毒的机制，人们知之甚少。