Effect of different anesthesia methods on erythrocyte immune function in mice

作     者：Wen-Long Zhang Meng-Ying Liu Zhen-Chen Zhang Chen-Yang Duan 

作者机构：Department of AnesthesiologyNo 175Hospital of PLA Affiliated Southeast Hospital of Xiamen University Department of AnesthesiologyThird Military Medical UniversityStudent Cadets' Teams 2 Department of AnesthesiologySouthwest HospitalThird Military Medical University 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2013年第6卷第12期

页      面：995-998页

核心收录：

学科分类：1002[医学-临床医学] 100217[医学-麻醉学] 10[医学] 

基　　金：supported by National Natural Science Foundation(No.81171035) 

主　　题：Isoflurane Ether Sodium pentobarbital Chloral hydrate Anesthesia Mice Erythrocytes Immune function 

摘      要：Objective:To explore effect of different anesthesia methods and different anesthetics on erythrocyte immune function in ***:The mice were anesthetized by isoflurane and ether inhalation,and also under intraperitoneal anesthesia with sodium pentobarbital and chloral hydrate,Blood was collected from the ventro-cardinal *** blood cell analyzer was used for routine blood examination,and the canthine oxidase method was used to measure the superoxide dismutase(SOD)*** peroxidation product malondialdehyde(MDA)was measured with TBA,and glutathione peroxidase(GSH-Px)was measured with DTNB,and then the effect of different anesthesia methods and different anesthetics on erythrocyte immune function in mice was ***:Hct level of chloral hydrate intraperitoneal injection group was significantly higher than the other three groups(P0.05).And the MDA levels in the pentobarbital sodium group were significantly higher than the other three groups(P0.05).SOD and GSH-Px of the chloral hydrate and sodium pentobarbital intraperitoneal injection group were significantly lower than the other two groups;RBC-C 3bRR and RBC-ICR of the chloral hydrate and sodium pentobarbital intraperitoneal injection group were significantly lower than the other two ***:Different drugs can induce changes in immune function of mice at different *** and ether have less damage to animal body,while chloral hydrate and sodium pentobarbital intraperitoneal injection have a certain inhibitory effect on the animal body respiratory system and can cause greater damage to the ***,the reasonable selection and control of anesthetics are very important in order to avoid the experimental errors caused by anesthesia.