Pathobiology of pulmonary hypertension: role of the serotonin transporter gene

作     者：Serge ADNOT,Saadia EDDAHIBI 

作者机构：INSERM U492 and Département de Physiologic Hpital H. Mondor AP-HP Créteil France INSERM U492 and Département de Physiologic Hpital H. Mondor AP-HP Créteil France 

出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))

年 卷 期：2003年第12期

页      面：168-170页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：role of the serotonin transporter gene in as with of Pathobiology of pulmonary hypertension that COPD PPH from 

摘      要：The role for serotonin(5-hydroxytryptamine, 5-HT)in controlling the pulmonary circulation was investigated following reports of an increased risk of primary pulmonary hypertension(PPH)in patients who used appetite suppressants that interact with 5-HT transport. In addition to its vasoactive effects, 5-HT exerts mitogenic and co-mitogenic effects on pulmonary artery smooth muscle cells(PA-SMCs), This effect is mediated through the serotonin transporter(5-HTT).