Effects of Chinese herbal medicine Xiangbin prescription on gastrointestinal motility

作     者：Zhi Jiang Li-Xing Cao Bo Liu Qi-Cheng Chen Wen-Fan Shang Lu Zhou Dan-Yan Li De-An Guo Zhi-Qiang Chen 

作者机构：Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Institute of Basic Medical SciencesChinese Academy of Medical SciencesBeijing 100005China Shanghai Research Center for Modernization of Traditional Chinese MedicineShanghai Institute of Materia MedicaShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 201203China 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2017年第23卷第16期

页      面：2987-2994页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by Guangdong Provincial Department of Science and Technology No.173 

主　　题：Antrotroduodenojejunal manometry Gastrointestinal motility Migrating motor complex Xiangbin concoction Motilin Ghrelin 

摘      要：AIM To investigate the effects of Xiangbin prescription(XBP), a Chinese herbal concoction, on gastrointestinal *** Forty healthy volunteers were recruited for this randomized controlled trial of XBP. Antroduodenojejunal manometry was used to monitor gastrointestinal motility in these subjects. After the subjects had fasted for at least 12 h, XBP(n = 30) or placebo(n = 10) was orally administrated and gastrointestinal motility was recorded for 4 h. Plasma motilin and ghrelin were measured by enzyme-linked immunosorbent *** Oral administration of XBP significantly increased the amplitude of duodenal contractions [19.5(13.0-26.7) vs 16.9(12.3-23.9), P 0.05], jejunal contractions [18.3(15.3-25.0) vs 15.4(11.7-23.9), P 0.01], and the motility index of duodenal contractions [522.0(146.0-139.0) vs 281.0(76.5-1006.0), P 0.01] in phase Ⅱ of the migratory motor complex(MMC), which subsequently initiated the MMC cycle [74.0(30.0-118.0) vs 116.5(24.0-219.0), P 0.05], shortened the duration of phase I of the MMC [42.0(0.0-90.0) vs 111.5(42.0-171.0), P 0.01], and lengthened the duration of phase Ⅱ of the MMC [120(21-240) vs 58(16-170), P 0.01] compared to the duration before XBP administration. There were significant differences in the amplitude of jejunal contractions [19.8(14.0-30.0) vs 18.0(13.0-28.5), P 0.05], the motility index of duodenal contractions [236.0(115.0-306.0) vs 195.0(109.0-310.0), P 0.05], and jejunal contractions [214.0(95.0-403.0) vs 178.0(55.0-304.0), P 0.01] in phase Ⅲ of the MMC. Oral administration of XBP greatly increased plasma motilin(57.69 ± 9.03 vs 49.38 ± 8.63, P 0.01) and ghrelin(279.20 ± 104.31 vs 238.73 ± 115.59, P 0.01) concentrations compared to concentrations after oral administration of the *** XBP can stimulate duodenal and jejunal motility and increase the concentrations of plasma motilin and ghrelin. The clinical applicability of XBP in treating GDIM deserves investigation.