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Effects of Chinese herbal medicine Xiangbin prescription on gastrointestinal motility

World Journal of Gastroenterology 2017年第16期23卷 2987-2994页

作者： Zhi Jiang Li-Xing Cao Bo Liu Qi-Cheng Chen Wen-Fan Shang Lu Zhou Dan-Yan Li De-An Guo Zhi-Qiang Chen Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510120Guangdong ProvinceChina Institute of Basic Medical Sciences Chinese Academy of Medical SciencesBeijing 100005China Shanghai Research Center for Modernization of Traditional Chinese Medicine Shanghai Institute of Materia MedicaShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 201203China

AIM To investigate the effects of Xiangbin prescription(XBP), a Chinese herbal concoction, on gastrointestinal *** Forty healthy volunteers were recruited for this randomized controlled trial of XBP. Antroduodenojejunal manometry was used to monitor gastrointestinal motility in these subjects. After the subjects had fasted for at least 12 h, XBP(n = 30) or placebo(n = 10) was orally administrated and gastrointestinal motility was recorded for 4 h. Plasma motilin and ghrelin were measured by enzyme-linked immunosorbent *** Oral administration of XBP significantly increased the amplitude of duodenal contractions [19.5(13.0-26.7) vs 16.9(12.3-23.9), P < 0.05], jejunal contractions [18.3(15.3-25.0) vs 15.4(11.7-23.9), P < 0.01], and the motility index of duodenal contractions [522.0(146.0-139.0) vs 281.0(76.5-1006.0), P < 0.01] in phase Ⅱ of the migratory motor complex(MMC), which subsequently initiated the MMC cycle [74.0(30.0-118.0) vs 116.5(24.0-219.0), P < 0.05], shortened the duration of phase I of the MMC [42.0(0.0-90.0) vs 111.5(42.0-171.0), P < 0.01], and lengthened the duration of phase Ⅱ of the MMC [120(21-240) vs 58(16-170), P < 0.01] compared to the duration before XBP administration. There were significant differences in the amplitude of jejunal contractions [19.8(14.0-30.0) vs 18.0(13.0-28.5), P < 0.05], the motility index of duodenal contractions [236.0(115.0-306.0) vs 195.0(109.0-310.0), P < 0.05], and jejunal contractions [214.0(95.0-403.0) vs 178.0(55.0-304.0), P < 0.01] in phase Ⅲ of the MMC. Oral administration of XBP greatly increased plasma motilin(57.69 ± 9.03 vs 49.38 ± 8.63, P < 0.01) and ghrelin(279.20 ± 104.31 vs 238.73 ± 115.59, P < 0.01) concentrations compared to concentrations after oral administration of the *** XBP can stimulate duodenal and jejunal motility and increase the concentrations of plasma motilin and ghrelin. The clinical applicability of XBP in treating GDIM deserves investigation.

关键词： Antrotroduodenojejunal manometry Gastrointestinal motility Migrating motor complex Xiangbin concoction Motilin Ghrelin

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